The Randle Cycle

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Paul Saladino6m · 2022-12-23

Claims Made

11

Claims Supported

11

Support Rate

100%

Support rate

11 of 11 claims supported

11 supported0 partial / not

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8

Well SupportedA high NAD to NADH ratio favors pyruvate dehydrogenase activity, allowing glucose metabolism through the Krebs cycle.Partially SupportedFree fatty acids inhibit glucose uptake into cells by downregulating glucose receptors that depend on insulin.Partially SupportedA high fat intake lowers the FAD to FADH2 ratio, impairing electron transport chain complex II activity and blocking glucose metabolism.Partially SupportedWhole milk contains approximately 20-25 grams of lactose and 5 grams of fat per serving.Partially Supported

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A. Volkovreader

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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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N. Park

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Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

The Randall cycle is primarily driven by the NAD to NADH ratio within mitochondria, which signals the cell's redox state and regulates pyruvate conversion to acetyl-CoA.

Partially SupportedMost meats, particularly lean meats, are not high in fat, and the fat they do contain is often short-chain fatty acids which are metabolized similarly to sugar and do not trigger the randle cycle.

Partially SupportedLow NAD+ levels favor the fatty acid synthase pathway from glucose-derived citrate.

Partially SupportedDietary fats contribute to fat accumulation and impair glucose metabolism and uptake.