A high NAD to NADH ratio favors pyruvate dehydrogenase activity, allowing glucose metabolism through the Krebs cycle.

“but if you're eating a lot of fat the NAD to the nadh ratio drops and then the buildup starts to happen and it basically pyruvate accumulates lactic accumulates and then the Krebs cycle is basically Krebs cycle is working because it's accepting acetyl-coa from the beta oxidation right because the that's how the fatty acids get oxidized but the the glucose that you're eating you cannot get metabolized for that reason”

“but if you're eating a lot of fat the NAD to the nadh ratio drops and then the buildup starts to happen and it basically pyruvate accumulates lactic accumulates and then the Krebs cycle is basically I mean Krebs cycle is working because it's accepting acetyl-coa from the beta oxidation right because the that's how the fatty acids get oxidized but the the glucose that you're eating it cannot get metabolized for that reason”

“that ratio basically turns out to be the primary regulator of where the pyruvite dehydrogenase will accept pyruvate and convert it into acetyl COA and then continue with the Krebs cycle in the electron transport chain or not in other words High ratio of energy to the nadh when you're very very oxidized what favors the activity of pyruvide the hydrogenase so you will not be accumulating pyruvate you will not be generating lactate”