Why does heart rate variability (HRV) decline with age? | Peter Attia and Joel Jamieson

Well SupportedThe decline in heart rate variability (HRV) with age reflects a loss of resilience and adaptability at the autonomic nervous system level.

Partially SupportedCardiovascular fitness, indicated by higher VO2max, is the most effective factor for increasing or preventing the decline of HRV.

Well SupportedHeart Rate Variability (HRV) is a significant biomarker for health and wellness and is clearly associated with age.

Partially SupportedPhysiological mechanisms for HRV decline with age are linked to mitochondrial density, mitochondrial function, immune system elements, and hormonal status.

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