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Rapamycin extends mouse lifespan 9–14%
NAD+ precursors reverse aging in humans
Blue-light glasses improve sleep quality
Walking 10 min after meals blunts glucose
Verdict change — caffeine half-life downgraded

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Are sugar substitutes dangerous? — Whalespan

Content›Video›Are sugar substitutes danger…

Are sugar substitutes dangerous?

Peter Attia7m · 2024-05-14

Claims Made

13

Claims Supported

4

Support Rate

31%

Support rate

4 of 13 claims supported

4 supported9 partial / not

Claims from this content

11

◐Partially SupportedPeter Attia avoids drinking calories, except for protein shakes sweetened with artificial sweeteners.◐Partially SupportedDoses of sugar substitutes consumed by humans are orders of magnitude lower than those used in studies that suggested toxicity.◐Partially SupportedAspartame data from around 2006-2007 showed higher cancer rates in rats consuming high amounts from birth, equivalent to about 20 cans of diet soda daily.◐Partially SupportedFirst-generation non-sugar sweeteners like saccharin, aspartame, and sucralose may have a slightly negative effect on body weight and glycemic control, even when calories are controlled.Well Supported

More from Peter Attia

Peter Attia on Zone 2 Cardio

Peter Attia on Rapamycin (with Matt Kaeberlein)

Attia walks back the clinic protocol: too aggressive for healthy adults

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AV

A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

NP

N. Park

2d

Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

✓

Bryan Johnson uses xylitol gum to prevent tooth decay.

◐Partially SupportedNon-nutritive sweeteners like xylitol, erythritol, stevia, and allulose appear to have less detrimental effects on metabolic parameters, with allulose potentially offering slight benefits on glycemic control.

?Limited ResearchArtificial sweeteners may be cancer-causing at normal human consumption doses, but it is not probable.

◐Partially SupportedIndividuals struggling with glycemic control or body weight should substitute artificial sweeteners with water, not sugar.

✕Not SupportedReplacing diet soda with regular soda is likely a worse outcome due to increased calorie intake.

◐Partially SupportedHigh doses of any substance, including oxygen or Tylenol, can be toxic.

◐Partially SupportedThe primary concerns with sugar substitutes are their metabolic effects and impact on gut health, rather than cancer risk at normal doses.