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Rapamycin extends mouse lifespan 9–14%
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Understanding autism's genetic links | Peter Attia & Wendy Chung — Whalespan

Content›Video›Understanding autism's genet…

Understanding autism's genetic links | Peter Attia & Wendy Chung

Peter Attia12m · 2023-09-03

Claims Made

29

Claims Supported

24

Support Rate

83%

Support rate

24 of 29 claims supported

24 supported5 partial / not

Claims from this content

19

✓Well SupportedAutism is highly heritable, estimated at 85-90%, with underlying genetic factors potentially differing among affected children.✓Well SupportedFamilial hypercholesterolemia is characterized by LDL cholesterol above 190 mg/dL (off medication) and is caused by thousands of different mutations.✓Well SupportedAt least 100 genes have been identified with high confidence as being associated with autism.✓Well SupportedChanges in DSM diagnostic criteria and increased recognition contribute to the observed increase in autism prevalence.Partially Supported

More from Peter Attia

Peter Attia on Zone 2 Cardio

Peter Attia on Rapamycin (with Matt Kaeberlein)

Attia walks back the clinic protocol: too aggressive for healthy adults

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A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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N. Park

2d

Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

◐

No single gene or genetic factor accounts for more than 1% of individuals with a clinical diagnosis of autism.

◐Partially SupportedAutism can be caused by inborn errors of metabolism like undiagnosed phenylketonuria (PKU).

◐Partially SupportedAnxiety and ADHD are frequent comorbid diagnoses associated with autism.

◐Partially SupportedLongitudinal studies of individuals with autism are scarce due to challenges like participant mobility, funding loss, and mortality.

◐Partially SupportedPrematurity at 26 weeks increases the probability of autism compared to being born at term (40 weeks).

◐Partially SupportedEpilepsy can be a comorbid condition with autism, with onset in childhood or adolescence.

◐Partially SupportedSome adult autism subtypes may be associated with neurodegenerative conditions linked to neuro-maintenance genes.

◐Partially SupportedGenes associated with autism may predispose individuals to obesity, potentially worsened by medications for behavioral conditions.

◐Partially SupportedMost current knowledge about autism is derived from studies of individuals up to approximately 20 years old.

◐Partially SupportedThe approximate prevalence of autism is currently around 2%.

◐Partially SupportedGenes with a global effect on brain function and cognition, such as those involved in gene regulation, may be associated with autism, intellectual disabilities, and epilepsy.

◐Partially SupportedMany genes associated with autism function in, are expressed in, and are active during intrauterine fetal brain development.

◐Partially SupportedOver 3,500 genes can be responsible for the phenotype of high LDL cholesterol.

◐Partially SupportedMany adults with autism were not diagnosed in childhood, and societal understanding and diagnostic criteria for autism have evolved over time.

◐Partially SupportedPrecision medicine approaches are needed for autism management due to its heterogeneity and prevalence.