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Weekly · Sunday Morning

Five longevity claims.
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Last Sunday

Rapamycin extends mouse lifespan 9–14%
NAD+ precursors reverse aging in humans
Blue-light glasses improve sleep quality
Walking 10 min after meals blunts glucose
Verdict change — caffeine half-life downgraded

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Is now the time for HERD IMMUNITY? The way forward or total catastrophe? — Whalespan

Content›Video›Is now the time for HERD IMM…

Is now the time for HERD IMMUNITY? The way forward or total catastrophe?

Paul Saladino22m · 2020-04-13

Claims Made

44

Claims Supported

21

Support Rate

48%

Support rate

21 of 44 claims supported

21 supported23 partial / not

Claims from this content

22

✓Well SupportedPositive coronavirus tests in recovered patients may be due to faulty tests or viral remnants, not reinfection.◐Partially SupportedThe fatality rate for coronavirus is less than 1.5%, and likely less than 1%.◐Partially SupportedA strategic approach to social distancing with more relaxed measures in areas with low hospital strain and stricter measures where strain is high is advisable.◐Partially SupportedA vaccine will not work if the immune system does not generate antibodies after exposure to a virus.Partially Supported

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AV

A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

NP

N. Park

2d

Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

◐

The case fatality rate for SARS-CoV-2 is likely less than 0.5%.

◐Partially SupportedThe ORF1a protein, involved in viral genome replication, can mutate, rendering drugs targeting it ineffective.

◐Partially SupportedCoronaviruses have approximately 30,000 base pairs and around 15 genes, including ORF1a, ORF1b, the S spike protein, ORF3, and the M protein.

◐Partially SupportedThe M protein of the virus is involved in evading or tolerating the host immune system.

◐Partially SupportedThe origin of SARS-CoV-2 most likely points to bats rather than other sources.

◐Partially SupportedThe S protein of coronavirus is a potential target for vaccines, but its mutation rate is a concern for vaccine efficacy.

◐Partially SupportedAssessing nutritional and metabolic health, such as fasting insulin levels, is necessary to determine who is truly healthy.

◐Partially SupportedNextstrain.org can be used to track coronavirus mutations and progression.

◐Partially SupportedGenetic sequencing analyses indicate the SARS-CoV-2 virus is not a laboratory construct.

◐Partially SupportedRapid virus mutation may diminish the value of vaccines or drugs targeting the spike protein.

◐Partially SupportedThe ORF1a polyprotein in coronavirus has cysteine-type endopeptidase activity, iron-II RNA binding, zinc-iron ion binding, and induces host autophagy.

◐Partially SupportedThe flu virus mutates, making yearly vaccine development challenging.

◐Partially SupportedThe ORF1a polyprotein is involved in viral genome replication and processing.

◐Partially SupportedIf the ORF1a protein mutates, drugs targeting it may become ineffective.

◐Partially SupportedMany people in Chicago have antibodies to SARS-CoV-2 without having had symptoms.

◐Partially SupportedSARS-CoV-2 is an RNA virus with surface proteins including an S protein, a lipid bilayer envelope, and an N protein.

◐Partially SupportedThe immune system will generate antibodies upon exposure to a virus, enabling herd immunity and progress.

◐Partially SupportedCoronavirus is exposing the poor metabolic health and nutritional status of the population.