Audit a URL →

Sign in Sign up free

Loading…

Weekly · Sunday Morning

Five longevity claims.
Worth your time.
Every Sunday.

Last Sunday

Rapamycin extends mouse lifespan 9–14%
NAD+ precursors reverse aging in humans
Blue-light glasses improve sleep quality
Walking 10 min after meals blunts glucose
Verdict change — caffeine half-life downgraded

5 audits·1 verdict change·0 affiliate links·Every Sunday

Joining 1,247 readers — founders, MDs, and longevity-obsessed people who fact-check their own health decisions.

Browse

Decisions Claims Content Creators

Product

Audit a URL Sunday roundup API (soon)Pricing

About

FAQ Methodology Editorial Standards Corrections Press & brand RSS feed

Legal

Terms of Service Privacy Policy DMCA

Finally, something serious in this space.
Because we actually read the papers.

© 2026 Whalespan. Independent, evidence-graded longevity.

Why a study might be stopped before its completion — Whalespan

Content›Video›Why a study might be stopped…

Why a study might be stopped before its completion

Peter Attia9m · 2023-09-12

Claims Made

12

Claims Supported

7

Support Rate

58%

Support rate

7 of 12 claims supported

7 supported5 partial / not

Claims from this content

9

◐Partially SupportedCETP inhibition increases HDL's capacity to act as a sink for toxic waste.◐Partially SupportedProspective clinical trials can be stopped prematurely for safety breaches, demonstrated benefit to one group, or futility.◐Partially SupportedChanging a single molecule in a drug can completely alter its mechanism and effects.◐Partially SupportedIt may be unethical to run further CTEP inhibitor trials if differences in death rates are observed across multiple trials.Partially Supported

More from Peter Attia

Peter Attia on Zone 2 Cardio

Peter Attia on Rapamycin (with Matt Kaeberlein)

Attia walks back the clinic protocol: too aggressive for healthy adults

Discussion

Native comments, Twitter mentions, and Reddit threads about this content — surfaced together so the conversation isn't fragmented across platforms.

M

Share your read of this content…

Posting publicly as you · linked to your social profiles

Sort by:

AV

A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

NP

N. Park

2d

Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

◐

The Look Ahead trial was stopped due to futility analysis, despite suggesting a 5% reduction in cardiovascular death risk.

◐Partially SupportedRandomized controlled trials are sometimes not feasible or ethical, leading to the use of observational studies.

◐Partially SupportedClinical trials may include pre-specified p-values for interim analyses to detect significant differences in endpoints like death.

◐Partially SupportedAt the time it was stopped, the Look Ahead trial showed a hazard ratio of 0.95 for cardiovascular death, with a 95% confidence interval of 0.83 to 1.09, indicating no statistically significant effect.

◐Partially SupportedThe COX-2 inhibitors Celebrex and Vioxx had similar efficacy, but Vioxx caused more side effects in a subset of hypertensive patients.