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Weekly · Sunday Morning

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Rapamycin extends mouse lifespan 9–14%
NAD+ precursors reverse aging in humans
Blue-light glasses improve sleep quality
Walking 10 min after meals blunts glucose
Verdict change — caffeine half-life downgraded

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Epigenetic Aging: How old is your DNA? — Whalespan

Content›Video›Epigenetic Aging: How old is…

Epigenetic Aging: How old is your DNA?

Rhonda Patrick4m · 2020-12-15

Claims Made

14

Claims Supported

13

Support Rate

93%

Support rate

13 of 14 claims supported

13 supported1 partial / not

Claims from this content

13

✓Well SupportedBiological age, rather than chronological age, is the key factor for healthspan.✓Well SupportedDNA methylation biological aging clocks estimate biological age using age-correlated DNA methylation changes.✓Well SupportedMultiple epigenetic clocks measured over time tend to be reproducible, especially in the absence of interventions.✓Well SupportedDifferent tissues have distinct biological age clocks, and a tissue-specific clock is more accurate.✓Well Supported

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A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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Approximately 400 genome sites can accurately predict chronological age.

✓Well SupportedTreatments based on epigenetics could prevent or slow age-related illnesses and potentially aging itself.

✓Well SupportedEpigenetics, specifically DNA methylation, can alter gene expression by adding or removing methyl groups, effectively turning genes on or off.

✓Well SupportedThe epigenetic DNA methylation clock is the best measure of true biological age.

◐Partially SupportedThe GrimAge clock can predict the risk of cancer, heart disease, and death.

◐Partially SupportedEpigenetic age acceleration occurs when DNA appears older than chronological age.

◐Partially SupportedEpigenetic clocks can be used to understand the mechanisms and processes of aging within cells.

◐Partially SupportedAn actual anti-aging drug may be closer than commonly perceived.

◐Partially SupportedA one-year drug trial reduced epigenetic age by two and a half years.