Bryan Johnson· Author
DNA methylation biological aging clocks use these changes to estimate a person's biological age, which can differ from their chronological age (how many years they've lived).
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
DNA methylation biological aging clocks use these changes to estimate a person's biological age, which can differ from their chronological age (how many years they've lived).
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We can read these changes using DNA sequencing or DNA hybridization chips. This is how we arrive at DNAme age clocks...
Epigenetic clocks (based on DNA methylation) can now predict your biological age and even show if lifestyle changes are slowing aging in real time, without waiting decades
um and what he's referring to is the mounting data that um the epigenetic changes are are the most descriptive of Aging um and are becoming more and more causally linked to uh to uh to to to aging events
the epigenetic changes are are the most descriptive of Aging — and are becoming more and more causally linked to — to — to to aging events
As you age, the methylation of your DNA changes in a predictable way — like clockwork.
So, there are a bunch of different types of epigenetic modifications but the type that these clocks are based on is something called CpG methylation or DNA methylation. And really what that means is you can look across, you know, one strand of DNA, and we know we have A, C, G, and T, but you have these regions which we call CpG sites, and that's where you basically just have a C right next to a G. But what happens is the CpGs can become methylated. Some of them are supposed to be methylated from the beginning. But what we find with aging is that the ones that we expect to have methylation lose methylation with aging, and the ones that shouldn't have methylation gain methylation with aging.
So, we're going to talk a little bit about these epigenetic clocks. And what these are are essentially just looking at DNA methylation patterns. And these methylation patterns are exactly that. They're a pattern that change with age. And the changing of these patterns really seems to pre be a precursor to the phenotype of aging into the outcomes of aging.