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Rapamycin extends mouse lifespan 9–14%
NAD+ precursors reverse aging in humans
Blue-light glasses improve sleep quality
Walking 10 min after meals blunts glucose
Verdict change — caffeine half-life downgraded

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The role of epigenetics in aging | Peter Attia and Alex Aravanis — Whalespan

Content›Video›The role of epigenetics in a…

The role of epigenetics in aging | Peter Attia and Alex Aravanis

Peter Attia7m · 2024-02-21

Claims Made

9

Claims Supported

7

Support Rate

78%

Support rate

7 of 9 claims supported

7 supported2 partial / not

Claims from this content

8

✓Well SupportedDNA methylation biological aging clocks estimate biological age using age-correlated DNA methylation changes.✓Well SupportedSmoking and obesity accelerate DNA methylation changes, while healthy diets slow them.✓Well SupportedThe epigenome is attractive for longevity research because it is readable and modifiable.✓Well SupportedDNA methylation changes occur predictably with age and contribute to age-related diseases like cancer.◐Partially Supported

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Peter Attia on Rapamycin (with Matt Kaeberlein)

Attia walks back the clinic protocol: too aggressive for healthy adults

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A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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N. Park

2d

Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

Technologies are emerging to modify the epigenome by remethylating and demethylating specific sites.

◐Partially SupportedRestoring DNA methylation status to a younger state may reverse age-related cellular changes.

◐Partially SupportedIf epigenetic reprogramming can restore cellular function to an earlier state, it could provide a concrete method for addressing aging.

◐Partially SupportedThe epigenome may regulate other Hallmarks of Aging, including mitochondrial dysfunction, nutrient sensing, and inflammation.