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Rapamycin extends mouse lifespan 9–14%
NAD+ precursors reverse aging in humans
Blue-light glasses improve sleep quality
Walking 10 min after meals blunts glucose
Verdict change — caffeine half-life downgraded

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Are all calories created equal? | Peter Attia and Rick Johnson — Whalespan

Content›Video›Are all calories created equ…

Are all calories created equal? | Peter Attia and Rick Johnson

Peter Attia11m · 2024-12-31

Claims Made

9

Claims Supported

7

Support Rate

78%

Support rate

7 of 9 claims supported

7 supported2 partial / not

Claims from this content

9

✓Well SupportedFructose consumption leads to insulin resistance, fatty liver, and hypertension, even when calorie intake is controlled.✓Well SupportedAnimals fed a 40% sugar diet became diabetic and developed severe fatty liver, unlike those fed a starch diet.◐Partially SupportedObesity is driven by biological pathways that increase food intake and decrease physical activity.◐Partially SupportedA diet with 40% sugar versus starch did not result in significant weight difference in a calorie-controlled study.Not Supported

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A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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N. Park

2d

Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

✕

The high fructose corn syrup industry uses short-term, isocaloric study findings to claim sugar is safe, but this misses the point that sugar itself causes hunger.

◐Partially SupportedFructose ingestion can lead to weight gain by increasing energy intake and decreasing energy expenditure.

◐Partially SupportedFructose has effects independent of calories, mediated by an energy depletion pathway that stimulates food intake.

◐Partially SupportedIn isocaloric studies where subjects are prevented from eating more, they experience hunger, which is not accounted for when claiming sugar is safe.

◐Partially SupportedIsocaloric diets of sugar versus starch show minimal difference in weight gain in animals over two months, with a slight increase due to decreased energy metabolism in the fructose group.