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Rapamycin extends mouse lifespan 9–14%
NAD+ precursors reverse aging in humans
Blue-light glasses improve sleep quality
Walking 10 min after meals blunts glucose
Verdict change — caffeine half-life downgraded

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Growth hormone as a longevity tool | Peter Attia & Nir Barzilai — Whalespan

Content›Video›Growth hormone as a longevit…

Growth hormone as a longevity tool | Peter Attia & Nir Barzilai

Peter Attia9m · 2024-11-22

Claims Made

16

Claims Supported

7

Support Rate

44%

Support rate

7 of 16 claims supported

7 supported9 partial / not

Claims from this content

12

◐Partially SupportedThe optimal range for Insulin-like Growth Factor 1 (IGF-1) is likely between the 60th and 80th percentile.✓Well SupportedIn centenarian females, lower IGF-1 levels predict longer longevity.✓Well SupportedGrowth hormone prescription can foster rehabilitation and healing from orthopedic injuries, such as bicep tears, over an eight-week period.✓Well SupportedHuman growth hormone (HGH) is undetectable by current drug tests and is likely the drug of choice in most sports.Partially Supported

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Attia walks back the clinic protocol: too aggressive for healthy adults

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A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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2d

Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

◐

Low IGF-1 may improve overall biology but not necessarily preserve muscle mass in older women.

◐Partially SupportedGrowth hormone may have indications for use after strokes and in early cognitive decline.

◐Partially SupportedGrowth hormone can improve vitality but may also accelerate aging.

?Limited ResearchThe optimal timing for starting geroprotective interventions like senolytics or metformin is uncertain.

◐Partially SupportedMost negative effects of growth hormone and IGF-1 in humans are observed in females, not males.

◐Partially SupportedGrowth hormone may have indications for use in specific medical contexts, such as after strokes or for brain health.

◐Partially SupportedAmong centenarians, women in the lowest quartile of IGF-1 levels do not have a higher likelihood of sarcopenia but exhibit better cognitive function and tend to live longer.

◐Partially SupportedWidespread daily use of growth hormone in geroprotective regimens has not yet shown a clear signal of premature death.