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Weekly · Sunday Morning

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Rapamycin extends mouse lifespan 9–14%
NAD+ precursors reverse aging in humans
Blue-light glasses improve sleep quality
Walking 10 min after meals blunts glucose
Verdict change — caffeine half-life downgraded

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Can Ketones Help the Brain When Glucose Fails? | Dominic D’Agostino, Ph.D. — Whalespan

Content›Video›Can Ketones Help the Brain W…

Can Ketones Help the Brain When Glucose Fails? | Dominic D’Agostino, Ph.D.

Peter Attia11m · 2025-12-12

Claims Made

22

Claims Supported

18

Support Rate

82%

Support rate

18 of 22 claims supported

18 supported4 partial / not

Claims from this content

22

✓Well SupportedAlzheimer's disease can be viewed as 'brain diabetes' where insulin resistance hinders neuronal glucose utilization.✓Well SupportedKetogenic therapies reduce systemic inflammation, improve brain energy metabolism, and change metabolic physiology.✓Well SupportedElevating ketones acutely can improve cognition in individuals with cognitive deficits.✓Well SupportedSystemic inflammation can lead to neuroinflammation, and injecting LPS can rapidly cause amyloid progression in mice.Well Supported

More from Peter Attia

Peter Attia on Zone 2 Cardio

Peter Attia on Rapamycin (with Matt Kaeberlein)

Attia walks back the clinic protocol: too aggressive for healthy adults

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AV

A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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N. Park

2d

Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

✓

Caffeine, Alpha GPC, or a combination of both can be used to safely spike adrenaline to enhance learning and memory.

◐Partially SupportedFasting should be used situationally rather than as a daily default.

✓Well SupportedAmyloid and tau accumulation in Alzheimer's disease may be a downstream consequence of inflammation.

◐Partially SupportedPatient selection for Alzheimer's interventions should prioritize individuals with significant glucose hypometabolism.

◐Partially SupportedKetone metabolic therapy with co-factors like lactate, creatine monohydrate, and alpha-ketoglutarate could be an intervention for Alzheimer's prevention.

✕Not SupportedSome individuals with high amyloid levels remain cognitively sharp, challenging the amyloid hypothesis for Alzheimer's disease.

◐Partially SupportedAlzheimer's disease may be addressed through metabolic therapies, particularly in patients with an energetic crisis.

✕Not SupportedAntibodies for Alzheimer's prevention are associated with significant costs, accessibility issues, and risks like cerebral hemorrhage.

◐Partially SupportedStudies are investigating if long-term ketogenic therapy can impact amyloid PET scan results over 2-10 years.

✕Not SupportedAlpha GPC may cause over-focus, over-stimulation, and affect sleep.

◐Partially SupportedA ketogenic formula intervention represents a low-hanging fruit for Alzheimer's prevention and treatment.

◐Partially SupportedA 2008 study showed caprylic triglyceride improved the Mini-Mental Status Exam.

◐Partially SupportedKetone metabolic therapy may reverse or mitigate vascular dementia, excess glutamate issues, and other conditions contributing to cognitive decline.

◐Partially SupportedA ketogenic intervention stabilized and extended progression in an Alzheimer's case report.

◐Partially SupportedThe brain's capacity to use ketones is preserved with age, unlike its capacity to use glucose.

◐Partially SupportedThe p75 receptor agonist or amplifier shows promise for Alzheimer's disease.

◐Partially SupportedAlpha-GPC may be beneficial in the context of cognitive deficit.

◐Partially SupportedKetone metabolic therapy should be considered a comprehensive metabolic therapy targeting multiple aspects.