The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
So he's done studies where patients aren't doing anything special with the diet. So they're eating whatever they normally eat, absolutely nonketogenic, giving them a ketone salt or ester, and then noticing immediate and direct changes in the metabolism of these metabolically compromised brain cells as measured by PET imaging.
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So Stephen Cunnane has done studies where he even gives ketone supplements. [...] And it has actually found that these brain metabolism deficits can be corrected, at least short-term, by giving a ketone supplement.
So I think what we can say that acutely if we elevate ketones in the context of a cognitive deficit we can improve cognition under a battery of different uh exams.
so I think >> of those would you say that the that the latter is the most important that it's the alternative fuel source that is the most important and what again let's go back to I I haven't paid any attention to this what's happening in clinical trials this is a much easier thing to test >> so has someone done the experiment where you take people in the earliest stages of dementia or in you know modest stages of of MCI mild cognitive impairment who are progressing towards dementia and you randomize them to standard of care versus the exact same standard of care plus a KD. Has that experiment been done cleanly in a randomized fashion? >> Those experiments like many things are ongoing and >> and I think you need you have the acute effects. So I I think what we can say that acutely if we elevate ketones in the context of a cognitive deficit we can improve cognition under a battery of different >> exams.