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Weekly · Sunday Morning

Five longevity claims.
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Rapamycin extends mouse lifespan 9–14%
NAD+ precursors reverse aging in humans
Blue-light glasses improve sleep quality
Walking 10 min after meals blunts glucose
Verdict change — caffeine half-life downgraded

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Avoiding, Treating & Curing Cancer | Dr. Alex Marson — Whalespan

Content›Video›Avoiding, Treating & Curing …

Avoiding, Treating & Curing Cancer | Dr. Alex Marson

Andrew Huberman2h 27m · 2026-03-09

Claims Made

225

Claims Supported

158

Support Rate

70%

Support rate

158 of 225 claims supported

158 supported67 partial / not

Claims from this content

158

✓Well SupportedAG1 is a vitamin, mineral, probiotic drink with adaptogens designed to meet foundational nutritional needs and provide insurance for adequate fruit and vegetable intake.✓Well SupportedComprehensive blood testing is vital for detecting many aspects of mental and physical health, and Function Health offers this affordably.✓Well SupportedAndrew Huberman's mercury levels decreased after limiting tuna, increasing leafy greens, and supplementing with NAC.✓Well SupportedFunction offers over 100 advanced lab tests for comprehensive bodily health assessment.Well Supported

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A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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N. Park

2d

Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

✓

Quality sleep, regulated by core body temperature changes, is foundational for mental health, physical health, and performance.

✓Well SupportedThe book 'Protocols: An Operating Manual for the Human Body' offers scientifically substantiated protocols for sleep, exercise, stress control, and focus/motivation.

✓Well SupportedTaking AG1 daily improves physical health, mental health, and cognitive and physical performance, as evidenced by noticeable differences during lapses in use.

✓Well SupportedMattress characteristics like softness, firmness, and breathability significantly impact sleep quality and should be tailored to individual needs.

✓Well SupportedAndrew Huberman consumes 16-32 ounces of water with a packet of Element upon waking, during exercise, and sometimes a third packet if exercising hard or sweating a lot.

✓Well SupportedElement is an electrolyte drink containing sodium, magnesium, and potassium in appropriate ratios without sugar, which is important for hydration and cellular function.

✓Well SupportedFunctional health testing includes biomarkers for toxins such as BPA and PFAS.

✓Well SupportedYamanaka factors can reprogram adult cells into pluripotent stem cells.

✓Well SupportedTherapy can be beneficial even on days when one does not feel like doing it.

✓Well SupportedEarly exposure to allergens like peanuts in infancy may help develop a robust immune system and reduce the likelihood of allergies.

✓Well SupportedCancer risk increases with age due to the accumulation of mutations over time as cells divide and accumulate damage.

✓Well SupportedCheckpoint inhibitors like anti-CTLA-4 and anti-PD-1 work by releasing the 'brakes' on T-cells to activate them against cancer cells.

✓Well SupportedCAR T-cells can cure leukemia and lead to long-term remission.

✓Well SupportedBRCA1 and BRCA2 are high-penetrance genes, meaning individuals with these mutations have a significantly elevated lifetime risk of developing breast or ovarian cancer.

✓Well SupportedLipid nanoparticles (LNPs) naturally tend to accumulate in the liver, making them useful for treating genetic diseases affecting liver cells.

◐Partially SupportedChimeric antigen receptor T-cells (CAR T-cells) are engineered T-cells that use artificial sensors to target cancers.

✓Well SupportedBRCA gene testing is recommended for individuals with a family history of breast cancer.

◐Partially SupportedInconsistent poor sleep negatively impacts all aspects of health and performance.

◐Partially SupportedFibromyalgia syndrome is defined as a constellation of signs and symptoms whose underlying mechanism is not understood.

◐Partially SupportedInsufficient sleep impairs cognitive function, increases reactivity, and makes individuals more susceptible to infections.

✕Not SupportedOverusing antibiotics carries the risk of ending the current era of effective antibiotic treatment due to the increase in antibiotic-resistant bacteria.

◐Partially SupportedBispecific antibodies can engage T-cells to target cancer cells locally without genetic modification of the T-cells.

✓Well SupportedCRISPR base editors can change nucleotides at a specific site without a double-stranded break by recruiting a deaminase domain.

◐Partially SupportedCRISPR technology can cut out undesirable genes, replace mutations, and enhance cell function.

✓Well SupportedComputational tools like AI enable new scales of biological experiments by extracting insights from large datasets.

◐Partially SupportedThousands to hundreds of thousands of different CRISPR modifications can be delivered into a population of T-cells from a blood sample, with each cell receiving a unique modification.

◐Partially SupportedCombining epigenetic programming with Yamanaka factors and genetic programming with CRISPR enables programmable cells for tissue regeneration and disease treatment.

◐Partially SupportedCRISPR was discovered as a bacterial immune system against viruses.

◐Partially SupportedThe immune system's response to pathogens can be systemic or localized.

◐Partially SupportedThe random generation of T-cell receptors creates a diverse repertoire capable of recognizing novel pathogens.

✓Well SupportedThe thymus is an organ where T-cells undergo critical education and development.

◐Partially SupportedTargeted drugs designed to inhibit specific cancer cell mutations have extended lives, but cancer cells can develop resistance by mutating.

◐Partially SupportedElectroporation uses a small electrical current to create transient pores in cell membranes, allowing substances like DNA or CRISPR complexes to enter.

✓Well SupportedSleep health is strongly associated with immune health.

✓Well SupportedCancer is caused by accumulated mutations in a cell's DNA that lead to uncontrolled growth and resistance to normal growth-inhibiting signals.

◐Partially SupportedDNA damage from smoking can accelerate the accumulation of mutations that lead to cancer.

◐Partially SupportedCAR T-cell therapy is an immune therapy where the body's own immune cells are engineered to selectively kill cancer cells.

◐Partially SupportedIn the thymus, T-cells that recognize self-targets are negatively selected and die, while those that do not recognize self-targets are positively selected.

✓Well SupportedGenetic predispositions like BRCA mutations increase cancer risk by increasing susceptibility to mutations.

?Limited ResearchIt is not yet clear which cancers may be more responsive to a ketogenic diet versus exacerbated by it.

◐Partially SupportedAntibiotics are effective for treating bacterial infections and have saved many lives.

◐Partially SupportedCAR T-cell therapy targeting CD19 is effective for leukemias because the body can tolerate the loss of healthy B cells expressing CD19.

◐Partially SupportedLipid nanoparticles can deliver mRNA into T-cells to temporarily create CAR receptors for cancer therapy.

◐Partially SupportedAntibody-drug conjugates append a drug to an antibody to selectively deliver it to cancer cells, increasing local concentration and avoiding systemic doses.

◐Partially SupportedThe ability to manufacture lipid nanoparticles at scale and deliver synthetic mRNA is a significant advancement in intervening in biology to treat disease.

◐Partially SupportedLentiviruses for CAR T-cell therapy have not significantly sparked an adverse immune reaction that outweighs the benefits of the therapy.

◐Partially SupportedCheckpoint inhibitors have shown remarkable success in treating melanoma.

◐Partially SupportedEngineered T-cells are being considered for treating autoimmune diseases like rheumatoid arthritis, childhood diabetes, and multiple sclerosis.

◐Partially SupportedThe immune system can be re-engineered to protect against cancer and other diseases.

◐Partially SupportedEngineered viruses and virus-like particles can be used to deliver genetic material to specific cells by engineering their tropism.

◐Partially SupportedCAR T-cells engineered to eliminate B cells are showing responses in early trials for lupus and other autoimmune diseases.

◐Partially SupportedViruses have evolved to be excellent shuttles for delivering genetic material into cells by hijacking cellular biology and genes.

◐Partially SupportedCAR T-cell therapy challenged the dogma that cancer immunotherapy should be ignored.

◐Partially SupportedSystemic antibiotics are likely to be crucial in saving a friend's vision threatened by a posterior chamber eye infection.

◐Partially SupportedCAR T-cell therapy has demonstrated significant success in treating certain types of leukemia and lymphoma.

◐Partially SupportedLipid nanoparticles (LNPs) are the technology used to deliver mRNA vaccines.

◐Partially SupportedCAR T-cells target and eliminate cancer cells once infused into a patient.

✕Not SupportedThere is a risk of losing human diversity if fads emerge in popular genes for offspring, especially when combined with IVF and genetic editing.

✕Not SupportedX-rays cause mutations and should be avoided if possible.

◐Partially SupportedLow glutamine diets are being explored in some scientific journals for potential health benefits.

✕Not SupportedExcessive UV exposure and sunburn are detrimental to skin cells and increase cancer risk.

◐Partially SupportedIf a mutation provides a cellular benefit, such as increased growth, that cell and its daughters will proliferate, potentially leading to cancer with further mutations.

◐Partially SupportedCancer is characterized by genetic changes leading to uncontrolled cell division.

◐Partially SupportedCells with deleterious mutations often undergo programmed cell death due to internal control mechanisms.

◐Partially SupportedmRNA vaccines use a temporary mRNA template for limited protein production by cells.

◐Partially SupportedThe mechanism by which poor sleep impairs the immune system is not fully understood and is often excluded as a variable in mouse studies.

◐Partially SupportedResearch in mice involved genetic modifications of the NMDA receptor to enhance plasticity.

◐Partially SupportedKetogenic diets might indirectly help with certain forms of dementia.

◐Partially SupportedmRNA is a temporary intermediate transcribed from DNA that serves as a template for protein synthesis.

◐Partially SupportedMutations increase cancer risk, though not all mutations lead to cancer.

◐Partially SupportedUpon activation, innate immune cells release signals that alert and recruit the adaptive immune system.

◐Partially SupportedUltra-processed foods are likely detrimental, but the optimal balance of whole foods for health and longevity requires clarification.

✕Not SupportedExposure to environmental and workplace hazards like mutagens and chemicals can cause DNA damage and increase cancer risk.

✕Not SupportedUV radiation from sun exposure is a risk factor for DNA damage in skin cells and can lead to cancer.

✕Not SupportedSmoking and vaping are mutagens that significantly increase cancer risk.

◐Partially SupportedCytokines are signaling molecules secreted by immune cells that can influence fever development.

◐Partially SupportedThe innate immune system acts as a first alarm system, identifying general signs of damage or foreign patterns not typically found in healthy human cells.

◐Partially SupportedShinya Yamanaka is creating a bank of immune-compatible iPSCs for transplantation.

◐Partially SupportedThe speaker consumes Element dissolved in water during physical exercise, especially on hot days.

◐Partially SupportedThe pharmaceutical industry is exploring engineered proteins, lipid nanoparticles, viruses, and engineered cells as new drug modalities.

◐Partially SupportedA technology allows lipid nanoparticles to be injected into the bloodstream and target T-cells by including a recognition protein.

◐Partially SupportedThe genetic modification of T-cells for CAR therapy in Emily Whitehead's case was performed using lentiviruses, which are modified HIV viruses, to deliver DNA encoding the CAR.

◐Partially SupportedAI models are being used to design synthetic proteins that recognize and bind to cancer cell surface targets for engineered cell therapies.

◐Partially SupportedThe immune system must balance being primed to fight infections with not attacking the body's own cells, and failure in either can lead to pathology.

◐Partially SupportedAutoimmune conditions can arise when T-cells develop a reaction or binding to the body's own naturally produced cells.

◐Partially SupportedAutoimmune diseases emerge when normal checks that prevent T-cells from recognizing self-antigens fail.

◐Partially SupportedSomatic edits modify DNA in individual cells but are not passed to the next generation and are the focus of CRISPR technology for engineering cells like those in the immune system.

◐Partially SupportedGenetic modification of human embryos using CRISPR technology has been performed.

✕Not SupportedCRISPR-Cas9 gene editing can introduce unintended consequences such as off-target cuts, DNA degradation, or chromosomal fragmentation.

◐Partially SupportedIntroducing genetic edits into an embryo results in every cell of the developing embryo having the edit, including sperm and eggs, leading to germline transmission.

◐Partially SupportedModifying human embryos with CRISPR-Cas9 to create 'super people' is ethically distinct from decisions about not implanting IVF embryos with genetic abnormalities.

◐Partially SupportedOptimizing electroporation conditions involves balancing the creation of pores large enough for CRISPR to enter with the need to prevent cell death.

◐Partially SupportedThe delivery of CRISPR into cells of interest, such as neurons or liver cells, could potentially involve direct surgical injection into organs.

◐Partially SupportedCRISPR was initially only used in artificial, immortalized cell lines and its application in real, non-immortalized human T-cells was unclear.

◐Partially SupportedCancer is a probabilistic disease resulting from mutations, and individuals can develop cancer even when doing everything 'right'.

◐Partially SupportedThe immune system is involved in every part of the body and has evolved to protect against infections, foreign invasions, and signs of damage.

◐Partially SupportedFever can help fight infection but also causes discomfort.

◐Partially SupportedModern medicine can reprogram the immune system to target cancer, inflammation, and autoimmunity by instructing cells using DNA and molecular biology.

◐Partially SupportedCumulative exposure to low-level radiation from airport scanners may increase cancer risk.

✕Not SupportedNutrition studies comparing red meat-rich and plant-based diets are often confounded by factors like sourcing and starches.

◐Partially SupportedCRISPR technology allows for genetic modifications in human cells for therapeutic T-cells.

◐Partially SupportedCRISPR therapy involves patient blood donation, cell culturing and freezing, followed by re-infusion.

◐Partially SupportedImproved early cancer diagnosis tools could be combined with immune-responsive treatments, with prevention as the goal.

◐Partially SupportedCRISPR technology allows the introduction of large DNA fragments into specific DNA sites.

◐Partially SupportedCrispr technology enables precise modification of the genome, allowing researchers to study the consequences of specific dna changes on cellular function and disease models.

◐Partially SupportedArsenal Biosciences can industrially scale the process of creating more powerful T-cells for tumor microenvironments by writing up to 10,000 nucleotides of DNA code into patient cells.

◐Partially SupportedThere is ongoing research into delivering CRISPR directly into the body to modify specific cells like T-cells, heart cells, or neurons.

◐Partially SupportedModified T-cells are engineered with resilience genes to persist longer and function more effectively within the tumor microenvironment.

◐Partially SupportedPesticides are implicated as potential mutagens and linked to higher cancer rates in rural areas near crop dusting zones.

◐Partially SupportedThe risks associated with vaccines should be considered in the context of the risks posed by the virus itself.

◐Partially SupportedAntibodies produced by B-cells are released into the bloodstream and provide protection against infections.

◐Partially SupportedLessons learned about gene behavior will provide a 'recipe book' for genetically modifying immune cells to achieve desired functions.

◐Partially SupportedForgetting certain things is useful and not necessarily a negative outcome.

◐Partially SupportedDeveloping CAR T-cell therapies for solid tumors is challenging due to difficulties in finding selective cancer targets and engineering cells that require multiple targets for activation.

◐Partially SupportedEarly life exposure to allergens and foods, and the development of tolerance, are critically important for building a robust immune system.

◐Partially SupportedImmunotoxins like Saporin attached to an antibody can target and kill specific cells, such as cancer cells, by binding to cell surface proteins.

◐Partially SupportedLipid nanoparticles tend to target the liver when injected.

◐Partially SupportedThe development of new antibiotics is an underfunded area of medicine.

◐Partially SupportedThere may be a spectrum of genetic influences on the immune system, ranging from diagnosed strong genetic consequences to more subtle, potentially multigenic factors.

◐Partially SupportedTherapeutic goals for autoimmune diseases involve making the immune system controlled and targeted, rather than using blanket immunosuppression.

◐Partially SupportedAutoimmune-like symptoms can occur when the immune system is highly activated due to overwork and poor nutrition.

◐Partially SupportedB-cells are lymphocytes that produce antibodies and work in coordination with T-cells.

◐Partially SupportedT-cells play a central role in coordinating and fine-tuning the immune response.

◐Partially SupportedIn obese mice fed a high-fat diet, antibodies used to block allergic responses were ineffective or worsened inflammation.

◐Partially SupportedA high-fat diet causes qualitative differences in immune system inflammation and cell responses in mice compared to a normal diet.

◐Partially SupportedHigh concentrations of food dyes in laboratory animals increase tumor and cancer incidence, but human food amounts are a tiny fraction.

◐Partially SupportedSystemic health has a significant impact on immune responses.

◐Partially SupportedCRISPR gene editing has improved precision and testing for off-target effects.

◐Partially SupportedDesigning a specific RNA molecule allows for a targeted CRISPR molecule to cut DNA at desired sequences.

◐Partially SupportedGene-editing technologies aim to become safer, more precise, and less costly for earlier cancer intervention.

◐Partially SupportedThe CRISPR-Cas9 system cuts DNA at specific sequences, guided by RNA for precise targeting.

◐Partially SupportedCrispr technology is being studied in plants to create drought-resistant crops and in every organ system to understand diseases and develop new molecular medicines.

◐Partially SupportedLipid nanoparticles enable new ways to intervene in biology for disease treatment, including delivering crispr or genetic material into cells.

◐Partially SupportedSingle-cell RNA sequencing combined with CRISPR allows for simultaneous measurement of all RNA within a cell and the specific CRISPR modification it received, enabling the readout of consequences for inactivating every gene in the genome of T-cells.

◐Partially SupportedThe deployment of CRISPR at a massive scale in primary human immune cells, with 22 million cells having a different CRISPR gene inactivated, provides a map of gene function consequences.

◐Partially SupportedThere is insufficient study on the risks of individual products and chemical exposures, and more investment is needed for clarity.

◐Partially SupportedCRISPR technology allows targeted changes in specific genomic locations to program cell behavior for T-cell engineering.

◐Partially SupportedInduced pluripotent stem cells can be engineered into T-cells to create a potentially limitless supply.

◐Partially SupportedMeat with a char, like barbecued meat, is implicated as a potential carcinogen.

◐Partially SupportedHarnessing the power of the immune system to target cancer is an effective approach to cancer treatment.

◐Partially SupportedChemical exposures in paints and thinners are potential mutagens.

✕Not SupportedBanking T-cells is not currently recommended, as the focus is on improving the ability to reactivate and re-engineer existing T-cells, even in patients whose T-cells have been depleted by chemotherapy.

◐Partially SupportedUnderstanding gene function provides a roadmap of cellular wiring and an instruction manual for T-cell immunotherapies.

◐Partially SupportedCRISPR-Cas9 technology can be used to scan DNA and cut at a particular sequence for gene editing.

◐Partially SupportedGenetic deficits can cause extreme susceptibility to certain infections or influence infection severity.

◐Partially SupportedCRISPR-based epiediting can turn genes on or off without cutting the genome.

◐Partially SupportedDNA replication is imperfect and can lead to mutations in daughter cells.

◐Partially SupportedPre-implantation genetic testing to avoid severe mutations that impair lifespan or quality of life is understandable.

◐Partially SupportedCOVID-19 infection results in mRNA transcription within cells, similar to mRNA vaccines.

◐Partially SupportedNaturally occurring mutations in the CCR5 gene can confer resistance to HIV.

◐Partially SupportedThe immune system can be directed to eliminate cancer cells while sparing healthy ones, achieving a durable response.

◐Partially SupportedBanking induced pluripotent stem cells could provide a source of cells for transplantation within a week.

◐Partially SupportedMedicine can now program cellular behavior in a directed way, representing a step-change in achievable interventions.

◐Partially SupportedThe adaptive immune system's major players are lymphocytes, specifically B cells and T-cells.