Matt Kaeberlein
Aging biology PI · Optispan podcast.
Should I take rapamycin?
For healthy adults at standard weekly doses: Partially Supported. For those with kidney issues or active infection: not without a physician.
Should I wear a continuous glucose monitor (CGM)?
Watch — for healthy adults without diabetes, the n=1 data is interesting but not yet linked to better outcomes.
Should I take NAD+ supplements or IV NAD+?
Ignore IV NAD+. NMN/NR oral supplements: Watch.
Should I take senolytics (D+Q, fisetin)?
Watch. Mouse data is provocative; human trials are early; protocols circulating online are ahead of the science.
Should I take GLP-1s for longevity (not obesity)?
For BMI < 30 without cardiometabolic indication: not yet. The off-label use outruns the safety data.
Should I take metformin off-label for longevity?
TAME hasn't finished. Existing cohorts mix diabetic and non-diabetic. The pop-culture case is ahead of the trial case.
5 g of creatine monohydrate daily improves muscle strength and lean mass in healthy adults at standard training loads.
Rapamycin extends median and maximum lifespan in mice across multiple lab strains and dosing protocols.
Weekly rapamycin dosing in healthy adults shows favorable safety and immune markers in early observational data.
mTORC1 inhibition is the mechanistic backbone for rapamycin's healthspan effects in mammals.
The PEARL trial showed an acceptable 48-week safety profile in healthy adults on weekly rapamycin.
Lifespan extension in female mice is consistently larger than in males across rapamycin studies.
Paste the URL — video, podcast, article, or paper — and we'll extract every claim and grade it against the literature.
Audit a URL →Native comments, Twitter mentions, and Reddit threads about Matt — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.