Should I take alpha-ketoglutarate (AKG)?

Our read is that alpha-ketoglutarate (AKG) is a promising longevity compound that has been successfully reproduced in experiments and is a central metabolite in the TCA and Krebs cycles that declines with age.

Experts suggest that supplementing with AKG may be beneficial, with some reporting it can reduce hair greying, frailty, extend median lifespan, and reverse epigenetic age.

While a controlled clinical trial is underway, preliminary findings and expert use indicate a positive impact in people.

Peter Attia has used a rejuvenant product containing alpha-ketoglutarate (AKG) for years, and some experts mention supplementing 18-month-old female mice with alpha-ketoglutarate and administering it at 1% in drinking water.

• 01Peter Attia and Rhonda Patrick state that alpha-ketoglutarate is a promising longevity compound that has been successfully reproduced in experiments.
• 02Peter Attia notes that funding translational research for aging interventions, such as the AKG trial costing $1-1.5 million, is a high-leverage investment for potentially adding a decade to lifespan.
• 03David Sinclair claims that molecules including alpha-ketoglutarate, acetate, lysine, S-adenosylmethionine, and NAD+ influence modifications to DNA and its packaging proteins.
• 04David Sinclair states that alpha-ketoglutarate can convert white fat into beige fat when administered at 1% in drinking water.
• 05