Bryan Johnson· Author
in mice: oral infection increased brain tau tangles by roughly 500% and amyloid plaques by 140%
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
in mice: oral infection increased brain tau tangles by roughly 500% and amyloid plaques by 140%
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Mice fed P. gingivalis through the mouth grew amyloid plaques in their brains. Hippocampal neurons died. The bacteria crossed the blood-brain barrier and started chewing through the same proteins that fail in human Alzheimer's patients.
Animal studies showed the bacteria play a role in more rapid disease progression.