The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
and the and the thing I'd lump in there with metformin is that berberine is kind of the Poor Man's metformin it's a tree bark extract that also dramatically lowers blood glucose yeah yeah and it mimics kind of that um fasting
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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
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Berberine from the ancient barberry is “poor man’s metformin.” Human studies report lower glucose, HbA1c, lipids at 1.5g/d.
The doses are high, one to two grams per day, but it does seem to work. And I think you said you got to take quite a bit of this stuff, though. Yeah, the clinical studies, it's at least a gram, there's one that worked with two grams, but it does seem to work just like Metformin in improving the body's sensitivity to insulin and lowering the blood glucose levels, which is a good sign that it's going to have future health benefits.
yep okay it's a from a tree bark it just happens to have these same properties yeah and by the way reducing mtor and reducing blood glucose yeah
Berberine - 600 mg three times per day (with meals). In meta-analyses, it reduces fasting glucose and HbA1c in people with type 2 diabetes.
And if we’re talking specifically about atherosclerosis, berberine has a much more compelling evidence base—it’s been shown to reduce plaque formation, while also improving LDL, HbA1c, and glucose regulation.