Creatine is at/near the top of the list.
The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
Creatine is at/near the top of the list.
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I've been recommending this to patients for 6 months now. The big shift is patients actually do it because the explanation is concrete.
Same in nutrition counseling. The before/after framing helps.
Tracking with a CGM on top of this for 3 months. Variability dropped quickly and stayed dropped.
Worth noting the 0.71 SMD in the Kreider meta is in trained athletes. Effect in untrained adults runs closer to 0.3 — still meaningful, but the panel should reflect that gradient.
Good catch. Could the brief surface the training-status interaction inline?
The top one though, of all of them by far that has an incredibly strong safety profile. It has, it is a cheap, it is a simple form to get, has a important magnitude of effect, and is effective across multiple domains of physical health and performance. And it is because of that it is my crown jewel. It is in my opinion, without question, the Michael Jordan of all supplementation. And that's creatine monohydrate.
Yeah, so touching on creatine, it is the most tested, safe, and effective support supplement we have. I mean, there are thousands of studies on creatine monohydrate now.
so that is is always number one on my list
Um, creatine has as Brian was mentioning earlier, like more data backing it than I think almost any other supplement that we're aware of. Um, and the data is overwhelmingly positive. Uh, there are certainly some studies that have shown no change, no benefit, but not studies that show harm. And there's a lot of studies that have shown benefit and not just one area, but multiple multiple areas of life.
I tell my parents because they don't eat just meat and I'm like look I were you I'd sell both creatine I think a lot of people should be I mean they're not weight lifters not bodybuilders it's basically a health supplement but it it has benefits in the gym as well absolutely
doses of up to 20 to 30 grams per day have been studied for five years in humans or more that's an incredible statistic to have five years of study of people taking that much creatine with no downsides
creatine is incredibly cheap there's really no downsides doses of up to 20 to 30 grams per day have been studied for 5 years in humans or more that's an incredible statistic to have five years of study of people taking that much creatine with no downsides
it it it increases lean body mass uh increases strength exercise performance and we're actually there's possibility that there's cognitive benefits as well
because this is just the lowest hanging fruit
Um, we can talk I want to talk a little bit about Creapure and some of the actual help. I want to give people some advice on how to go buy creatine because if you go to Amazon, it's like what do I which one do I buy? Um, but who who's sort of taken the mantle on trying to understand this because it is an important question and if you've got something that's insanely cheap, completely safe, has other benefits in the body anyway, and all we're really trying to figure out is, hey, should we all just be doubling our dose from 5 to 10? I' it'd be great to quantify the effect size and stratify patients that we need to be reaching out to because again not everybody listening to us is doing this anyway and it's just one more thing to ask somebody to do which comes at a cost right there's a psychic cost to just asking people to do more stuff and it's one more thing you got to do um so it would just be I mean again this is like lowhanging fruit in the world of of biomedical research
I'm definitely coming around to the view that creatine really seems to be a great general purpose supplement.
the bulk of the research is done using monohydrate and 99% of all the thousands of papers and the one I I hear a lot is there's a better bioavailable form than monohydrate I'm like wait a minute creatin monohydrates bioavailability is near 100%
in my opinion why mess with a good thing and probably because the efficacy and safety behind it
creatine monohydrate is that still the gold standard for supplementing with creatine if so why yeah it's the only standard so when I say creatine today it's monohydrate and the reason being it's is based on its safety and efficacy
5 g of creatine monohydrate daily improves muscle strength and lean mass in healthy adults at standard training loads.
Creatine improves cognitive performance, especially under sleep deprivation and high cognitive load.
Creatine improves cardiovascular health markers and reduces all-cause mortality risk.
Creatine supports bone-mineral density in post-menopausal women when paired with resistance training.
Women need higher creatine doses (8–10 g/day) than men to reach the same intramuscular saturation.