Early waking and an inability to fall back asleep despite exhaustion are common symptoms of major depression, indicating disrupted sleep architecture.

“part of what depression is, is that it's a dysregulated circadian system. And so mentors of mine say, if you can just get the sleep better, that's half the battle of dealing with depression. 'Cause so many people have insomnia around depression and have a whole host of types of insomnia. Having a hard time falling asleep, waking up in the middle of the night, and waking up earlier, all symptoms of depression.”

“what we know is that depression will disrupt your sleep and make your sleep shorter and it comes back to your comment from uh from Carl from Carl di we often see that patients will have problems staying asleep they wake up in the middle of the night they can't get back to sleep it's problematic and therefore their sleep duration and their Sleep Quality decrease”

“another Hallmark of major depression is people waking up at 2: or 3:00 a.m. and not being able to fall back asleep”

“And one of the most common symptoms of people with major depression, one of the signs of major depression, is early waking, and not being able to fall back asleep despite being exhausted. So, waking up at 3:00 AM or 4:00 AM or 5:00 AM, just spontaneously, and not being able to go back to sleep.”

“Insomnia is associated with depression, metabolic disease, and early mortality.”