The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
The AgRP neurons stimulate eating. ... So, the activity in these AgRP neurons goes way up when animals or people are starved. And I don't mean starved for long periods of time, but I mean when they haven't eaten for a while.
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
If you were to stimulate the AgRP neurons, animals or people eat like crazy. They will eat to the point where they burst.
you have a hypothalamic area called the arcuate nucleus. It's a fascinating area. It's actually the area that houses, these PMOC neurons and these other types of neurons that regulate hunger and satiety. And these neurons in the arcuate nucleus start getting active. When we see food and think about food, they drive hunger
there's a companion set of neurons called palc neurons that promote satiety so there sort of the yin and yangang of hunger arrp neurons promote hunger pomc neurons promote satiety they're intermingled in the same part of the hypothalamus they they're axons that project to the exact same Downstream brain regions then it's thought that these two neurons compete with each other uh to control appetite
so the first thing I'd say is they are present in humans and humans uh do humans have hrp neurons human arrp neurons Express the leptin receptor and we think the functions are very similar
first of all there are a set of neurons in this arcu nucleus it's the Pro opio melanocortin system now the Palm C neurons make something called Alpha msh melanocyte stimulating hormone Alpha melanocyte stimulating hormone msh reduces appetite and it's a powerful molecule all right so just put that on the shelf msh reduces appetite
now there's another population of neurons in the aru nucleus called the agrp neurons the arrp neurons stimulate eating the activity in these agrp neurons goes way up when animals or people haven't eaten for a while
Ghrein is a hormone that increases depending on how long it's been since we ate last. Okay? So, the longer it's been since we had a meal, ghrein levels are going to be higher and higher and higher. And it essentially makes us hungry by interacting with particular neurons in an area of the brain called the arcuate nucleus of the hypothalamus and some other areas as well like the lateral hypothalamus.