The immune system's response to pathogens can be systemic or localized.

“I can I can imagine like with a splinter, of course, you're going to get a localized response. >> It's a little piece of wood or metal and so you're going to get the innate response and you're going to get some pus around it and it'll kind of localize the wound. But >> when it comes to an invasive virus like the cold virus, uh it overtakes us, right? The production of mucus, we got the headache, like the and I think it's the systemic effect that um that intrigues me so much. like where is the signal to to to launch a systemic versus a localized response in the immune system? How does it determine that?”