The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
we kind of talk about whitey Mao is not all it's cracked up to be it's probably just a marker for insulin resistance and so it's probably going to be associated with cardiovascular disease but not causing cardiovascular disease
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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
is getting a high level of TMAO from insulin resistance the same as getting a high level of TMAO from choline and carnitine not in this ball no way no way this is the same thing as the LDL story is getting a high level of LDL related to insulin resistance the same thing as getting a high level of LDL related to a ketogenic or carnivore diet nope not the same phenotype at all these are divergent phenotypes
TMAO is a great example of this. People are probably familiar with trimethylamine oxide. I talked about this on a previous podcast with Tommy Wood, but levels of TMAO, higher levels of TMAO are associated with heart disease. Okay, so everyone in medicine says TMAO causes heart disease. Therefore, you should limit choline and carnitine, which are valuable nutrients for your brain and your antioxidant defense system. Except what we find when we do the research is that insulin resistance also raises TMAO and insulin resistance also increases our risk of cardiovascular disease. And so, it's probably a a reverse causality, meaning that insulin resistance is causing TMAO to rise and TMAO looks like it's abnormal when in fact it has nothing to do with it.