Bryan Johnson· Author
+ Age-related gene programs reversed: SRC 39% (upregulated) / 30% (downregulated); WTC reversed fewer (Fig. 2C–D, no exact percentages reported).
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
+ Age-related gene programs reversed: SRC 39% (upregulated) / 30% (downregulated); WTC reversed fewer (Fig. 2C–D, no exact percentages reported).
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+ Standout tissues: • Skin: SRC −5.6 years vs WTC −4.4 years • Lung: SRC −4.1 years vs WTC −3.3 years • Skeletal muscle: SRC −4.9 / −3.5 years vs WTC −3.2 / −2.4 years • Spleen: SRC −2.6 years vs WTC −1.9 years • Hippocampus: SRC −2.0 years vs WTC −1.5 years
+ Average transcriptomic rejuvenation: SRC −3.34 years (54% of tissues) vs WTC −2.80 years (31% of tissues).
+ DNAmAge: Brain −5 years, skeletal muscle −4 years, spleen −2 years with SRC; WTC changes negligible.
Transcriptomic and epigenetic analyses confirmed biological age reversal in organs like skin, aorta, lungs, and the digestive system.
+ Reproductive system: Ovaries SRC −4.5 years vs WTC −3.1 years; granulosa cells showed >6 years reversal with SRC.
On average, this corresponded to estimated 3–5 years of biological age reversal, across 54% of tissues (vs 31% with WTCs).
+ Equivalent immune rejuvenation: SRC 3 years vs WTC 1.5 years (observational estimate, not author statistic).
SRCs outperformed conventional stem cells, reversing multiple hallmarks of aging across organ systems.