mTOR is a nutrient-responsive kinase that aligns with calorie restriction data for lifespan extension.

“Lower levels of certain amino acids, branch chain amino acids, are good for the cell because they downregulate mTOR activity.”

“mTOR is a sensor for amino acids particularly branched chain amino acids and you know we can probably get into a food fight about this one we should animals at least and even yeast cells having lower interactivity makes them live longer right and that is naturally done by having low levels of branched chain amino acids right”

“mtor is um the sensor for amino acids particularly branch chain amino acids”

“animals at least and even yeast cells having lower mtor activity makes them live longer right”

“the so basically the branching amino acids have not shown the same negative effects that the uh you know the methion system have shown in fact there are several studies when I first got into this the biogenic committee I was reading a Blog called Ergo log it's published by a bunch of bodybuilders in the Netherlands and they listed a study there where basically mice were being fed extra branching amino acids at a rate of like two percent of the food intake per day those were extra on top of what was already there and this increased the mice maximum lifespan by about I think 15 to 20 that's a lot”

“we certainly know that mtor which you brought up a moment ago is an amino acid sensor”

“And mTor is a nutrient responsive kinace so it responds to the levels of carbohydrates and and also amino acids that the cell encounters and so that fit into the calorie restriction data which I'm sure you've talked about that reducing calories can extend lifespan.”