Andrew Huberman· PhD
If you turn on the SIRT1 gene, the SIRT2 that we work on, in the hypothalamus that actually, will extend lifespan.
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
If you turn on the SIRT1 gene, the SIRT2 that we work on, in the hypothalamus that actually, will extend lifespan.
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Haim Cohen’s lab has shown, using a variety of mouse strains, that overexpression of SIRT6 extends lifespan (~15% in males PMID: 22367546) and 27% in males & 15% in females (PMID: 34050173)…
Eg. Shin Imai’s team discovered SIRT1 extends mouse lifespan when overexpressed just in the brain! 🧠
Both SIRT1 & SIRT6 can extend a mouse’s lifespan when overexpressed…
when you overexpress the gene in the brain for example it will extend lifespan and other sirtuins do that as well
other people have shown that that activation or overexpression of sirtuins and worms or flies or mice can have interesting effects on aging
there are a couple of studies that show in one case a brain specific activation of one of the sirtuins called certio1 could slightly extend lifespan and another that that over expression of a different sir 2 in 36 could slightly extend lifespan i think only in males
other people have shown that that activation or over expression of sirtuins and worms or flies or mice can have interesting effects on aging