Hyperbaric oxygen therapy resulted in a 2.6% increase in telomere length over 60 sessions for Bryan Johnson.

“Following 21 HBOT sessions, I am over 2/3 the way towards: i. increasing the telomere length of my immune cells by 18.3%-25.7% ii. reducing senescence in my immune T-cells by 12.21%-19.66%”

“telomerase activity of a 12 year old, associated with biological age”

“My telomere length in March 2024, six months before starting my HBOT protocol, measured 11.4kb. After 60 sessions at 90 minutes each, I re-tested on January 20, 2025: 11.7 kb. That’s a 2.6% increase.”

“Objectively small. But context matters. Though it is a small gain of 2.6%, it’s an improvement of an already optimized marker in my case.”

“Moreover, the study found a significant decrease in the fraction of senescent T-cells at the end of the protocol Ref (8).”

“A landmark clinical trial showed evidence of HBOT increasing telomere length in a small cohort of healthy older adults (age >64 years). Increases of telomere length of 20%-38% were demonstrated in multiple types of circulating immune cells, the effect was also sustained 1-2 weeks after ending the HBOT protocol Ref (8).”

“Now, one study we referenced for this therapy was in an older population, the Hbot was efficacious in increasing the length of telomeirs by up to 38%, and reducing scinesscent cells by up to 37%.”

“and my telomeirs lengthened.”

“They did. In the immune system, looking at these immune cells, you can measure senescence. You can stain them blue, which is bright blue when you get older, and they found that there was a dramatic reduction in the number of those senescent cytotoxic T-cells, as they're called.”

“Yeah, they took 30 people and put them in their large chamber, the one that I visited. And they did 60 daily sessions of 90 minutes, five of those per week, and had a look at the number of senescent cells in the bloodstream before and after and telomere length. And what they found remarkably was that those aspects of aging were reversed.”

“what the science says is that it actually can reverse an aspect of aging, which is telomere shortening.”

“memory improvements, telomeres, T helper cells. - Right. They go up as well. So in cognitive performance, there were those six elderly patients suffering from memory loss. And in 2021, this new study came out and they all improved.”

“a story came out of israel which i'm sure you've been emailed about as many times as i have you haven't okay well consider yourself lucky because i've only been emailed it about 57 times which is apparently the most rigorous study in the history of humans demonstrating the anti-aging benefits of hyperbaric oxygen so you see rich in this amazing study done in israel a group of volunteers were exposed to hyperbaric oxygen and wouldn't you know it their telomeres lengthened a bit”

“The hyperbaric oxygen treatment increased telomere length in blood cells and decreased the number of senescent immune cells.”

“Hyperbaric oxygen therapy led to a 38% increase in telomere length in blood cells and 37% fewer senescent immune cells in healthy older adults.”