David Sinclair· PhD
During the late 80s - 90s, genetic screens in simple organisms such as yeast, worms, and flies identified single gene mutations that could dramatically extend lifespan… 8/10
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
During the late 80s - 90s, genetic screens in simple organisms such as yeast, worms, and flies identified single gene mutations that could dramatically extend lifespan… 8/10
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
Um, surprisingly, there were like 300 genes that that met that description. And that one thing I learned from that is that extending lifespan at least in a simple organism like yeast and there's also data in worms is much easier than anybody would have ever expected
But anyway, we one of the main main things we hit was the mtor pathway and downstream of it is protein translation we hit a lot of things in protein translation
So in the 1980s, the big breakthrough was that there are...and early '90s, that there are genes that control aging. We call these longevity genes, do not call them anti-aging genes.