Andrew Huberman· PhD
found that turning on the sirtuin six gene, middle of the seven, number six gene is very potent. It extended the lifespan dramatically of mice that he engineered both males and females, which is great.
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
found that turning on the sirtuin six gene, middle of the seven, number six gene is very potent. It extended the lifespan dramatically of mice that he engineered both males and females, which is great.
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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
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And one of my first postdocs, actually literally my first postdoc, Chaim Cohen, published a great paper and found that turning on the Sirtuin 6 gene, remember there's seven, number six gene is very potent; it extended the lifespan dramatically of mice that he engineered, both males and females, which is great.
Boosting levels of the NAD-sensitive enzyme SIRT6 extends the lifespan of mice by a whopping 30%!!
helping explain why mice with extra SIRT6 live longer
Haim Cohen, my first postdoc (thank you!), who is credited for discovering SIRT6 extends mouse lifespan, wrote a nice review on this topic @BIU_Aging