Andrew Huberman· PhD
Well, it turns out that smoking increases what are called reactive oxygen species. This greatly disrupts the quality of the egg at the level of the spindle and mitochondria and a number of other features. And in the sperm, turns out that smoking doesn't necessarily disrupt the sperm directly, although it can cause DNA fragmentation, which can cause all sorts of abnormalities, can prevent fertilization, can lead to birth defects in the offspring.