The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
Metformin also slowed down aging in multiple organs including the brain, liver, lung, kidney, and skin, upon 40-months of treatment in 12 adult male cynomolgus monkeys, as indicated by novel multifactorial aging clocks.
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Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
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male Monkeys showed up to 6 years rejuvenation in brain activity, equivalent to 18 human years.
Metformin also reduced chronic inflammation, a known hallmark of aging.
Over 40 months, metformin slowed aging markers in monkeys, with a ~6-year regression of brain aging, preserving brain structure and enhancing cognition 👏 👏 https://t.co/mLofa7ZEtB https://t.co/4dqU7ZBzWw
Monkeys treated with metformin were approximately “6 years younger” [@agingdoc1: Metformin slows aging process, study shows [More precisely, epigenetic markers. Editorial views by Linda Brent, PhD and Ben Carlson at the Parsemus Foundation 👨🏻⚕️] https://t.co/DL2M7Stk0i https://t.co/2TaCNrXCnN]
40 months of treatment of monkeys with the diabetes drug metformin was associated with younger ages in ProteinAge, DNAmAge & TranscriptAge clocks, compared to an untreated group.
DNAmAge of major organs was 3-6 years younger