Andrew Huberman· PhD
given the number of people that seem to be exploring off label use of Metformin, I suggest educating oneself on the potential (studied) testosterone lowering effects and the defects seen to male offspring genitalia.
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We can't find evidence that holds up here. Proponents are reasoning from mechanism or analogy rather than direct human data, and the most credible skeptics raise objections we can't dismiss.
given the number of people that seem to be exploring off label use of Metformin, I suggest educating oneself on the potential (studied) testosterone lowering effects and the defects seen to male offspring genitalia.
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Metformin, the type 2 diabetes drug taken to slow aging, may increase the chances of a birth defect in offspring by 1.9%.
they summarize it there's significantly increased rates of hypospadias which is where the urethra goes to the bottom of the penis rather than out the end of the penis in men taking metformin