Metformin has benefits that extend beyond glucose regulation, such as effects on dementia, cancer, and heart disease.

“there were many benefits that that you know we see in metformin that go far beyond its uh glucose regulatory benefits they the obvious benefit that the diabetic patients get yeah no no n would be quite emphatic about disagreeing with me on this um I I'd love to be wrong about that but I just if I had to put my money it's just because most clinical trials fail and most clinical trials fail because they were based on Mouse data to start off with at least so maybe this is maybe this is something do it's certainly worth figuring out just because the effects are so manifold you know it's it's it's dementia and cancer and heart disease and we don't know what else”

“the observational evidence ignoring the banister paper just the observational the consistency of the observational data that it reduces dementia cancer cardiovascular disease suggest to me there's enough smoke there to look to see if there's if there's the keys article and then you can rethink that”