David Sinclair· PhD
Gut bacteria convert choline from RED MEAT into TMA, which becomes TMAO, a chemical that may cause cardiovascular disease.
The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
Gut bacteria convert choline from RED MEAT into TMA, which becomes TMAO, a chemical that may cause cardiovascular disease.
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These are contained in things like milk, cheese, eggs, organs, meat. Well, all of the foods that I'm a huge fan of. They go into your body. Here they have kind of an obese person. There's a little bit of perhaps subliminal messaging there. I would redraw that person to have six-pack abs, nice pecs, a good tan, and maybe some sun-bleached hair. Maybe they're a surfer, maybe they're just a rock climber, maybe they're just a very healthy individual if they're eating all those foods. Nevertheless, the the association is not lost on me here. It is true that these compounds, carnitine and choline, get metabolized by gut microbiota and eventually form a compound called called trimethylamine, which is then metabolized via an enzyme in the liver called FMO, flavin monooxygenase, into trimethylamine oxide.
these compounds carnitine and choline get metabolized by gut microbiota and eventually form a compound called trimethylamine which is then metabolized via an enzyme in the liver called fmo flavin mono oxygenase into trimethylamine oxide