Bryan Johnson· Author
Replacing saturated fats (5% of total calorie intake) with MUFAs was associated with a 15%, 10%, and 11% decrease in all-cause, heart disease, and cancer mortality risk.
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
Replacing saturated fats (5% of total calorie intake) with MUFAs was associated with a 15%, 10%, and 11% decrease in all-cause, heart disease, and cancer mortality risk.
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High intake of mono-unsaturated fatty acids (MUFAs) is associated with a 6% reduction in all cause mortality risk, compared to an 8% increase for high intake of saturated fats.
In a meta-analysis with 1,164,029 participants as well as in a prospective cohort study with 521,120 participants, plant MUFAs consumption reduced all cause mortality risk by 6%. (5) (6)