Psilocybin treatment caused human cells to stay younger longer, divide more times before aging, and maintain intact, healthy chromosome ends.

“+ Upregulated Gene Expression: Upregulation of DNA repair and anti-oxidant gene expression (Sirt1, PCNA, Nrf2), and a dose-dependent decrease in reactive oxygen species (ROS).”

“+ Telomere Length Restoration: Over 50% increase in telomere length compared to control in aged cells. + Reduced Senescence Markers: Over 40% reduction in the key senescence marker B-Gal in aged fibroblasts, along with cell-cycle arrest markers p16 and p21.”

“+ Increased Doubling Divisions: 29% and 51% increase in doubling divisions with 10µM and 100µM psilocin, respectively, with no signs of carcinogenicity (no immortalization; all cells eventually ceased dividing).”

“Psilocybin increased cellular lifespan in human fibroblasts (treated with psilocin, the active metabolite) by increasing cellular divisions (no oncogenic effect observed) + delaying replicative senescence and reducing senescence markers in aged fibroblasts + preserving telomere length/preventing their attrition in aged fibroblasts + enhancing antioxidant & DNA-damage response pathways”

“Psilocybin helped human cells live longer in the lab. The cells stayed younger for longer and kept dividing more than usual before aging out. And the protective tips on DNA (telomeres), which wear down with cell divisions, stayed intact for longer.”

“The treated cells stayed younger for longer, divided more times before aging out, and the end of their chromosomes stayed intact and healthy longer.”

“The study published in July by Kato et al. shows that psilocybin via psilocin) extended the “lifespan” of cultured human skin and lung cells by over 50–57% & delayed aging signs like reduced ox stress and telomere shortening”