David Sinclair· PhD
And one of the reasons that I believe it's true is that in model organisms, take a worm, if you turn up his shock proteins, either by giving them a lot of heat or genetically modifying them, they also live longer.
Loading…
The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
And one of the reasons that I believe it's true is that in model organisms, take a worm, if you turn up his shock proteins, either by giving them a lot of heat or genetically modifying them, they also live longer.
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
And one of the reasons that I believe it's true is that in model organisms, if take a worm, if you turn up heat shock proteins, um either by giving them a lot of heat or genetically modifying them, they also live longer.
Heat shock proteins have been of interest in the field of aging for a long-time, because there's evidence across the evolutionary tree that suggest they may be involved in aspects of longevity. People with two copies of the HSP 70 (heat shock protein 70) allele that makes it more active (as does sauna use) live on average 2 years longer than people with no copies of it and 1 year longer than people with only one copy. This really suggests there is clearly a gene dose-dependent effect.
a gene polymorphism that increases the expression of more heat chock proteins is associated with being a centenarian
4–7 sauna sessions per week, 20 minutes at 80°C+, reduce cardiovascular mortality risk by 40% over a decade.
Regular sauna use raises BDNF and improves verbal memory in older adults.
Sauna protocols only generate the longevity effect when sessions exceed 30 minutes.
Hot-tub bathing yields cardiovascular benefits comparable to traditional Finnish sauna at matched core-temp dose.