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Rapamycin extends mouse lifespan 9–14%
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How Sauna Use May Boost Longevity — Whalespan

Content›Video›How Sauna Use May Boost Long…

How Sauna Use May Boost Longevity

Rhonda Patrick9m · 2015-04-28

Claims Made

23

Claims Supported

22

Support Rate

96%

Support rate

22 of 23 claims supported

22 supported1 partial / not

Claims from this content

16

✓Well SupportedFinnish men using sauna 4-7 times per week have 40-50% lower cardiovascular disease incidence and 40-50% lower all-cause mortality compared to those using it once a week.✓Well SupportedSauna use can positively impact physiological aspects comparable to moderate aerobic exercise, such as blood pressure and heart rate variability.✓Well SupportedSitting in a sauna at 163°F (73°C) for 30 minutes increased heat shock proteins, including Hsp70, by 50% over baseline, with the elevation sustained for 48 hours.✓Well SupportedSauna use activates heat shock proteins (HSPs), which help fold proteins correctly, stimulate pathways for building new blood vessels, and increase mitochondria.Well Supported

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Rhonda Patrick on Sauna Use

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A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

✓

Rhonda Patrick typically uses the sauna for over 30 minutes at 175-180°F (79.4-82.2°C) when not immediately following a training session.

✓Well SupportedA single 30-minute Finnish sauna session can lower blood pressure and improve arterial compliance in individuals with at least one cardiovascular risk factor.

✓Well SupportedDeliberate heat exposure may extend life by activating the FOXO3 genetic program, which is involved in DNA repair and clearing senescent cells.

✓Well SupportedFoxO3 increases the expression of genes involved in immune function, thereby improving the immune system's ability to fight pathogens and cancer.

✓Well SupportedFOXO3 upregulates pathways related to DNA repair and the clearance of senescent cells, which is important for maintaining health and cognition.

✓Well SupportedDeliberate heat exposure activates heat shock proteins, which prevent protein aggregation and plaque formation in the cardiovascular system and brain.

✓Well SupportedIncreasing heat shock proteins extends lifespan in model organisms like worms.

✓Well SupportedExposing fruit flies to a 70-minute heat stimulus that activates heat shock proteins can extend their lifespan by 15%.

◐Partially SupportedFOXO3 acts as a master regulator that enhances cellular resilience to age-related stresses.

◐Partially SupportedA polymorphism increasing FOXO3 expression is linked to a 2.7-fold increased chance of living to 100.

◐Partially SupportedFoxO3 increases the expression of genes involved in metabolism and stem cell function.

◐Partially SupportedThe average temperature of dry saunas used in the study was 79°C (174°F) for up to 20 minutes, and results may not directly apply to lower-temperature hot tubs, steam rooms, or infrared saunas.