Sauna use activates heat shock proteins (HSPs), which help fold proteins correctly, stimulate pathways for building new blood vessels, and increase mitochondria.

“it's well established in animal models and in humans, that sauna exposure of the sort that I described earlier activates these heat shock proteins.”

“So um having these heat shock proteins around, making sure they're they're properly taking care of our our proteins so they're not aggregating in our brains and in our in our plaques could be another potential way that sauna is protecting from Alzheimer's disease”

“HSPs are a major contributor to the health benefits from sauna and if core body temp isn't hit the tsunami doesn't happen.”

“And then there's other things that are happening too. So when you when you're sick, your body creates a fever, right? The one of the things that fever does is it activates these these chemicals called heat shock proteins. And heat shock proteins um are called these chaperones of proteins, which means they kind of usher proteins around and help them move around your body. And they also help um fix any misfolding of those proteins. So when when you're sick, you know, some of your proteins get messed up. Um your heat shock proteins come around, they refold those proteins for you. They help them help them work better basically.”

“What we think goes on in a sauna is you're activating HSPs. And these heat shock proteins are helping to fold proteins correctly and also stimulate pathways that are beneficial, such as building new blood vessels, making more mitochondria.”

“What we think goes on in a sauna is you're activating HSPS and these heat shock proteins are helping to fold proteins correctly and also stimulate pathways that are beneficial such as building new blood vessels, making more mitochondria.”

“there's the whole heat shock protein part where you know the heat stress is one of the major ways to increase heat shock proteins which do you play an important role in near general preventing neurodegenerative diseases”

“it's also really hard to the effects on the the vascular system which is important right as well because it's having such a profound effect on the back of their system the heat stress it's hard to uncouple well how much of the staving off of dementia and alzheimerís has to do with that versus heat shock proteins”

“the heat shock proteins, what they do is they prevent proteins from misfolding and forming aggregates, right? Well, it turns out the heat shock proteins stay active for a long time and so they end up having this like effect where you're now just improving the folding of proteins in general even after you're out of the hot sauna, right?”

“We also cover effects of heat stress on longevity & heat shock proteins, different sauna types, & combining with cold shock.”

“activation of heat shock proteins occurs with one heat stress (ie. one sauna use).”

“Heat shock proteins (activated by sauna) interact with beta-amyloid in the brain to prevent clumping in Alzheimer's.”

“Heat shock proteins produced in response to heat stress may prevent the damaging neurodegenerative effects of protein aggregation.”

“HSPs (increased in sauna) have been shown to protect gut barrier function.”

“heat stress such as using the sauna activates heat shock proteins and this has been associated with increased lifespan in worms and flies”

“I've talked a lot about the sauna and how the sauna is a good hormetic stress, it activates heat shock proteins which have a variety of positive effects. It also changes brain function as well. It changes the opioid system, endorphins, makes you more sensitive to them, so I became very interested in that.”

“So when you heat-stress the body, what happens is that you activate a signaling pathway called heat shock proteins. They play a very important role in maintaining the three-dimensional structure of a protein, which is important, obviously, for protein's function, but it's also very important for the half-life of the protein. And when the three-dimensional structure of a protein becomes misfolded because of damage that's occurring, you know, damage that, damage their DNA, the same damage that does that damages these proteins, you know, by-products of normal metabolism. Reactive oxygen species, by-products of, you know, immune activation, these things are damaging our proteins, our DNA, our cells. But heat shock...so when those proteins become damaged, they misfold, and they don't get degraded properly. So when this happens in brain, you know, proteins can start to then aggregate and form these plaques, protein aggregates and plaques. So probably the most well-known one is amyloid-beta 42, which is associated with Alzheimer's disease. But interestingly, heat shock proteins, what their function is inside of the cell is to actually repair a misfolded protein so that it maintains its proper three-dimensional structure again. So they're basically preventing the protein aggregation, and this has been shown in multiple studies in rodents, in lower organisms. There's been many, many studies, associated studies looking at heat shock proteins and neurodegenerative diseases. So there is a lot of interest in how heat shock proteins may be a therapeutic target for preventing neurodegenerative diseases like Alzheimer's and also Parkinson's disease.”

“what happens when you have a sauna, yes, you may induce some heat shock protein, great, that's important, and it can be important in folding of proteins, but what also happens, of course, is that you detox.”

“being acclimated to heat such as from regular sauna use results in the production of more heat shock proteins under normal conditions and even more so under stressful conditions such as cell and tissue injury”

“in fact there's been multiple uh you know animal studies showing that If You Give a Mouse you know like a amalo beta plaque sort of what we we get with humans in Alzheimer's disease and you express the heat shog proteins make them highly Express that uh they don't get the Alerus like symptoms and it helps with the plaque uh Aggregates and stuff”