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Weekly · Sunday Morning

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Rapamycin extends mouse lifespan 9–14%
NAD+ precursors reverse aging in humans
Blue-light glasses improve sleep quality
Walking 10 min after meals blunts glucose
Verdict change — caffeine half-life downgraded

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Important labs: fasting insulin & prolactin — Whalespan

Content›Video›Important labs: fasting insu…

Important labs: fasting insulin & prolactin

Paul Saladino8m · 2023-04-19

Claims Made

21

Claims Supported

18

Support Rate

86%

Support rate

18 of 21 claims supported

18 supported3 partial / not

Claims from this content

20

✓Well SupportedA fasting insulin level below 5 micro IU/mL is considered healthy.✓Well SupportedFasting insulin is the best test to assess insulin sensitivity, which is the most important metric for human health.✓Well SupportedSubsidizing fasting insulin tests could allow identification of metabolic dysfunction due to high reference ranges.✓Well SupportedRecommended prolactin levels are less than 15, and ideally less than 10.✓Well Supported

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A. Volkovreader

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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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A high DHEAS to cortisol ratio is a predictor of longevity in humans.

◐Partially SupportedManaging baseline cortisol levels may help address elevated fasting insulin.

◐Partially SupportedThe ratio of morning cortisol to DHEA-S is an indicator of stress levels and longevity trajectory.

◐Partially SupportedRemoving sugar from the diet in the form of fruit and honey is not a problem for humans and does not address elevated fasting insulin.

◐Partially SupportedLimiting omega-6 intake and not overdoing omega-3 polyunsaturated fatty acids are considered the two main drivers of insulin resistance.

◐Partially SupportedProlactin levels around 10.5 to 11.8 micro IU/mL can be elevated for the speaker.

◐Partially SupportedFasting insulin and prolactin are important blood tests that are rarely performed by mainstream physicians.

◐Partially SupportedElevated prolactin can indicate a pituitary adenoma and interfere with sex drive, libido, and weight loss.

◐Partially SupportedIn metabolically healthy males, prolactin returns to baseline quickly after orgasm.

◐Partially SupportedFasting insulin levels around 3.2 micro IU/mL are considered normal for the speaker, while 5.8 is an outlying high value.

◐Partially SupportedGut inflammation, potentially triggered by endotoxin from gram-negative bacteria, can cause elevated cortisol.

◐Partially SupportedProlactin levels can be elevated due to poor sleep or fatigue.

◐Partially SupportedTo address elevated fasting insulin, manage baseline cortisol and limit intake of omega-6 and omega-3 polyunsaturated fatty acids.

◐Partially SupportedEndotoxin from gram-negative bacterial cell walls can cause gut damage, leading to elevated cortisol.

◐Partially SupportedMeasuring cortisol throughout the day provides more comprehensive insights into health, stress, and insulin resistance than a single morning measurement.

◐Partially SupportedElevated fasting insulin and subclinical insulin resistance can be identified and addressed to improve metabolic health.