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Potential risks associated with TRT in women | Peter Attia and Derek MPMD — Whalespan

Content›Video›Potential risks associated w…

Potential risks associated with TRT in women | Peter Attia and Derek MPMD

Peter Attia15m · 2024-03-02

Claims Made

32

Claims Supported

0

Support Rate

0%

Support rate

0 of 32 claims supported

0 supported32 partial / not

Claims from this content

24

◐Partially SupportedPersonal experimentation with intranasal testosterone in women with low testosterone did not show a significant impact on libido in the hours following administration.✕Not SupportedReplacing testosterone in women to levels exceeding their physiologic peak in their 30s has no compelling justification and can lead to androgenization.◐Partially SupportedTestosterone levels in premenopausal women are 10-50 times higher than estrogen and progesterone levels when converted to equivalent units.◐Partially SupportedIntranasal testosterone is quicker acting than injectable testosterone due to its lack of fat depot accumulation, necessitating frequent dosing.

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Attia walks back the clinic protocol: too aggressive for healthy adults

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A. Volkovreader

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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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◐Partially Supported

Nesteo's intranasal testosterone administration is designed for quicker action and requires frequent dosing.

◐Partially SupportedWomen with near-unmeasurable testosterone levels may experience severe acne at physiologic replacement doses if their baseline was lower.

◐Partially SupportedTestosterone therapy in women is approached with caution due to a lack of extensive supporting data compared to estrogen and progesterone.

◐Partially SupportedLong-term use of combined oral contraceptives can suppress hormone levels and skew baseline measurements.

◐Partially SupportedA woman's baseline testosterone level may be lower than typical for her age group, making higher replacement doses supra-physiologic for her.

◐Partially SupportedHigh androgen levels can create a positive subjective feeling.

◐Partially SupportedThe hormonal effects of localized progestins and other forms of birth control beyond combined oral contraceptives are not well-documented.

◐Partially SupportedSupra-physiologic hormone replacement in women aims for symptom relief and optimization.

◐Partially SupportedIt is unlikely that women are being pushed to 200-300 ng/dL testosterone without developing severe cystic acne and facial hair.

◐Partially SupportedWomen may not notice subtle changes from hormone therapy as much as others, leading to delayed recognition of virilization.

◐Partially SupportedFemale bodybuilders may use oxandrolone (Anavar) or primobolan (metenolone) for super-physiologic muscle growth, which are more anabolic and less androgenic than testosterone.

◐Partially SupportedSome women monitor voice tone in real-time using decibel recorders to detect potentially irreversible masculinizing changes when using testosterone or during TRT.

◐Partially SupportedSome clinics market testosterone for women by emphasizing benefits like improved libido, quality of life, glucose management, and muscle growth.

◐Partially SupportedA female patient experienced masculinizing changes within weeks of starting HRT with a cream, prescribed by a practitioner who promotes 200-300 ng/dL total testosterone levels in women.

◐Partially SupportedSome women may compromise on side effects to maintain the perceived benefits of high-dose hormone replacement therapy.

◐Partially SupportedTotal testosterone levels between 200-300 ng/dL in women exceed peak physiologic levels.

✕Not SupportedSupra-physiologic testosterone dosing in women can lead to virilization outcomes if not closely monitored.

✕Not SupportedReplacing lost hormones to levels exceeding a woman's physiologic limit in her 30s lacks a compelling rationale.

◐Partially SupportedFemale bodybuilders may use testosterone doses similar to male physiologic levels, or avoid it due to masculinization.

◐Partially SupportedAccidental or intentional administration of testosterone at 10x the prescribed dose to a female patient resulted in clitoral enlargement within one month, which was reversible upon dose correction.