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Rapamycin extends mouse lifespan 9–14%
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Controversial Thoughts 7/2: Neu5Gc and Rhonda — Whalespan

Content›Video›Controversial Thoughts 7/2: …

Controversial Thoughts 7/2: Neu5Gc and Rhonda

Paul Saladino9m · 2020-07-02

Claims Made

14

Claims Supported

6

Support Rate

43%

Support rate

6 of 14 claims supported

6 supported8 partial / not

Claims from this content

12

✓Well SupportedHumans likely consumed meat with saturated fat throughout evolution, and meat consumption may have driven brain growth.◐Partially SupportedMuskellids that prey on small mammals rich in Neu5Gc do not exhibit massive cancers, suggesting Neu5Gc is not inherently harmful.◐Partially SupportedHumans lost the ability to synthesize N-glycolylneuraminic acid (Neu5Gc) approximately two to three million years ago due to a mutation in the enzyme CMAH.◐Partially SupportedThere are no human studies showing N-glycolylneuraminic acid (Neu5Gc) or antibodies against it are problematic.Not Supported

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AV

A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

NP

N. Park

2d

Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

✕

The fear-mongering around red meat and Neu5Gc is not based on real evidence and should not deter people from eating red meat.

✕Not SupportedThe hypothesis that Neu5Gc exposure is an immunologic trigger in humans is not supported by evidence.

◐Partially SupportedNeu5Gc, a sialic acid present in meat and organs, is unlikely to be harmful to humans.

✕Not SupportedConcerns about Neu5Gc are based on contrived mouse studies and are not applicable to humans.

✕Not SupportedRhonda Patrick's concerns about Neu5Gc are not scientifically sound and are comparable to the misguided focus on broccoli sprouts.

◐Partially SupportedEvolutionarily, humans are meant to consume red meat, and concerns about Neu5Gc, TMAO, and mTOR are largely unfounded.

◐Partially SupportedMouse studies introducing N-glycolylneuraminic acid (Neu5Gc) into knockout mice are not a good model for studying its effects in humans.

◐Partially SupportedA study of kidney transplant recipients who received rabbit polyclonal IgG (containing Neu5Gc) showed no increased incidence of colon cancer.