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Rapamycin extends mouse lifespan 9–14%
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AMA #9: Kratom Risks, Does Infrared Sauna Work & Journaling Benefits — Whalespan

Content›Video›AMA #9: Kratom Risks, Does I…

AMA #9: Kratom Risks, Does Infrared Sauna Work & Journaling Benefits

Andrew Huberman27m · 2023-07-28

Claims Made

45

Claims Supported

19

Support Rate

42%

Support rate

19 of 45 claims supported

19 supported26 partial / not

Claims from this content

37

✓Well SupportedThe physiological sigh, a breathing pattern of a double inhale followed by an extended exhale, can reduce stress in real-time.✕Not SupportedYoung males with a predisposition to psychosis should avoid high-concentration THC cannabis.◐Partially SupportedKratom is highly addictive but may assist some individuals in discontinuing opioid use.◐Partially SupportedPhysiological sighs are spontaneously engaged to correct imbalances in carbon dioxide and oxygen levels.◐Partially Supported

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A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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N. Park

2d

Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

It is impossible to become addicted to a substance or behavior that has never been taken or engaged in.

◐Partially SupportedApproximately 8% to 10% of people experience an increased dopamine response to alcohol, a subgroup at high risk for alcohol use disorder.

✕Not SupportedIndividuals with a history of potent positive responses to opioids or a strong aversion to stopping cannabis use should avoid kratom.

◐Partially SupportedKratom can be used to wean off prescription opioids like morphine and hydrocodone.

◐Partially SupportedUsing kratom to come off opioids can lead to increasing kratom dosages, potentially resulting in effects comparable to morphine or hydrocodone.

◐Partially SupportedIndividuals using cannabis for anxiety may experience withdrawal symptoms after 10 days without it.

◐Partially SupportedMitragynine, the major alkaloid in kratom, has weak affinity for opioid receptors and does not significantly contribute to painkilling effects.

◐Partially SupportedKratom can be used to achieve an opioid-like effect, a mild sedative effect, or a euphoric effect.

✕Not SupportedAndrew Huberman personally dislikes taking prescribed opioids like Vicodin post-surgery, preferring to manage pain without them due to nausea and feeling terrible.

✕Not SupportedIf the medial glute activation protocol exacerbates pain, it should be stopped immediately.

◐Partially SupportedKratom has opioid-like properties and may reduce cravings for other substances by binding to opioid receptors.

◐Partially SupportedOpioids suppress physiological sighing by binding to brainstem receptors, leading to reduced respiration and potentially death during sleep.

◐Partially SupportedThe risk of respiratory failure increases with higher dosages of kratom.

◐Partially SupportedAddiction can be defined as the progressive narrowing of the things that provide pleasure.

◐Partially SupportedMorphine and hydrocodone act as endogenous opioids at much higher potency than kratom, crossing the blood-brain barrier to bind to receptors such as the mu-opioid and kappa opioid receptors.

◐Partially SupportedKratom, especially combined with opioids or alcohol, can suppress respiration and is a potential cause of kratom-induced death.

◐Partially SupportedThe evaluation of any substance, including cannabis, alcohol, or kratom, should focus on potential benefits versus potential risks.

✕Not SupportedSupplements that are opioid compounds, such as kratom, warrant caution due to high abuse and addiction potential.

◐Partially SupportedOpioids activate the body's endogenous opioid system by binding to opioid receptors.

◐Partially SupportedAddiction is defined as continuing to use a substance or engage in a behavior despite negative consequences.

◐Partially SupportedA subgroup of people (10-40%) respond more potently to opioids.

◐Partially SupportedKratom product alkaloid concentrations vary, making direct comparison difficult.

✕Not SupportedKratom has addictive potential similar to potent opioids.

◐Partially SupportedBetween 10% and 40% of people are at significant risk for opioid addiction due to a potent positive response.

◐Partially SupportedKratom can be habit-forming and addictive, particularly at higher dosages, leading to withdrawal symptoms.

◐Partially SupportedBetween 10% and 40% of people respond to opioids in a particularly potent way, experiencing significant euphoria.

◐Partially SupportedKratom indirectly activates dopamine and serotonin systems, contributing to its addictive potential.

◐Partially SupportedKratom should be considered an opioid due to its pharmacological effects and addictive potential.

◐Partially SupportedBlocking the mu-opioid receptor prevents individuals from experiencing the euphoric, analgesic, or sedative effects of kratom, even at low doses.

◐Partially SupportedThe 'runner's high' is a mild euphoric state induced by long-duration repetitive exercise, caused by the body releasing endogenous opioids.

◐Partially SupportedPeople highly susceptible to opioid addiction may exhibit anxiety about abstaining from kratom for a week.

◐Partially SupportedKratom, morphine, and hydrocodone bind to the mu-opioid receptor, causing opioid-like effects.

◐Partially SupportedPeople can become addicted to kratom itself, even without prior opioid use.