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Rapamycin extends mouse lifespan 9–14%
NAD+ precursors reverse aging in humans
Blue-light glasses improve sleep quality
Walking 10 min after meals blunts glucose
Verdict change — caffeine half-life downgraded

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Defining and diagnosing dementia and Alzheimer’s disease — Whalespan

Content›Video›Defining and diagnosing deme…

Defining and diagnosing dementia and Alzheimer’s disease

Peter Attia11m · 2021-06-10

Claims Made

16

Claims Supported

10

Support Rate

63%

Support rate

10 of 16 claims supported

10 supported6 partial / not

Claims from this content

13

✓Well SupportedAmyloid PET scans have about 97% accuracy in diagnosing Alzheimer's disease in living people compared to post-mortem analysis.✓Well SupportedAlzheimer's patients typically exhibit forgetfulness and repetition while retaining long-term memory.◐Partially SupportedAmyloid PET scans cost approximately $4,000 out-of-pocket and are not covered by insurance.◐Partially SupportedThe diagnosis of Alzheimer's disease is primarily based on clinical assessment rather than histological confirmation, unlike cancer.Partially Supported

More from Peter Attia

Peter Attia on Zone 2 Cardio

Peter Attia on Rapamycin (with Matt Kaeberlein)

Attia walks back the clinic protocol: too aggressive for healthy adults

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AV

A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

NP

N. Park

2d

Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

◐

Distraction and normal aging can cause forgetfulness, such as forgetting names or tasks, which is distinct from dementia.

◐Partially SupportedFDG PET scans measure brain glucose metabolism and can provide patterns supporting different dementia diagnoses.

◐Partially SupportedThe core of dementia diagnosis relies on a clinical interview with the patient and an observer, supplemented by cognitive testing and brain imaging.

◐Partially SupportedNeuropsychological testing and PET scans may be necessary for specific dementia diagnoses, such as frontotemporal dementia (FTD).

◐Partially SupportedDementia can often be diagnosed accurately using MRI and FDG PET imaging without CSF analysis.

◐Partially SupportedLab tests are used in dementia diagnosis to rule out reversible causes of memory loss like thyroid disturbances or vitamin deficiencies.

◐Partially SupportedFrontotemporal dementia can present with preserved memory but significant changes in language or behavior, and may be misdiagnosed as bipolar disorder.

◐Partially SupportedStress and poor sleep can affect memory and cognitive function, similar to early dementia symptoms.

✕Not SupportedTertiary syphilis is too uncommon to routinely test for as a cause of memory loss.