Why I don’t worry about my “elevated” LDL

PS

Paul Saladino6m · 2022-06-24

Claims Made

14

Claims Supported

12

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86%

Support rate

12 of 14 claims supported

12 supported2 partial / not

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10

Well SupportedFasting insulin levels, ideally below 5 and preferably below 3, are crucial for assessing insulin sensitivity.Well SupportedMetabolic dysfunction, specifically insulin resistance, is the primary event leading to atherosclerosis, not LDL directly injuring the endothelium.Well SupportedImpaired wound healing at the endothelial level in individuals with insulin resistance prevents proper repair, leading to the initiation of atherosclerosis.Well SupportedWhile the correlation between elevated LDL and improved outcomes in infection is not causal, LDL is beneficial to the immune system.Well Supported

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A. Volkovreader

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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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N. Park

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Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

Maintaining insulin sensitivity can mitigate artery damage, and LDL may be involved in the atherosclerotic process in damaged arteries but does not initiate it.

Well SupportedA high LDL cholesterol level may not always be detrimental, particularly for individuals who are insulin sensitive.

Partially SupportedInsulin resistance can be assessed by triangulating measurements of triglycerides, hemoglobin A1c, and fasting glucose.

Not SupportedDoctors often focus on LDL cholesterol and overlook other indicators of insulin sensitivity, which is a critical oversight.

Partially SupportedLDL is essential for survival.

Partially SupportedGenetically low HDL levels do not always indicate insulin resistance.