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Weekly · Sunday Morning

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Rapamycin extends mouse lifespan 9–14%
NAD+ precursors reverse aging in humans
Blue-light glasses improve sleep quality
Walking 10 min after meals blunts glucose
Verdict change — caffeine half-life downgraded

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Fructose does not cause NAFLD — Whalespan

Content›Video›Fructose does not cause NAFL…

Fructose does not cause NAFLD

Paul Saladino5m · 2023-04-22

Claims Made

15

Claims Supported

15

Support Rate

100%

Support rate

15 of 15 claims supported

15 supported0 partial / not

Claims from this content

12

✓Well SupportedHealth influencers, nutritionists, and physicians should present clinical outcomes and personal blood work to support their dietary recommendations.✓Well SupportedA high fructose diet can alter LDL cholesterol levels and significantly increase triglycerides.◐Partially SupportedThe available evidence is not robust enough to conclude that fructose, high fructose corn syrup, or sucrose consumption affects NAFLD in humans.◐Partially SupportedA ketogenic diet can increase cortisol, a stress hormone, which may negatively affect aging.Partially Supported

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AV

A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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N. Park

2d

Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

◐

An animal-based diet can raise LDL but improves insulin sensitivity, leading to low hs-CRP, high testosterone, and great vitality.

◐Partially SupportedCortisol, not fructose, causes fatty liver disease, and stress leads to NAFLD through excess gluconeogenesis.

◐Partially SupportedDietary fat, particularly saturated and polyunsaturated seed oils, stimulates the development of NAFLD in rats more potently than dietary fructose.

◐Partially SupportedIn young rats, high sucrose intake ameliorates hepatic triacylglycerol accumulation promoted by restraint stress.

◐Partially SupportedHigher fructose intake is inversely associated with the risk of NAFLD in older Finnish adults.

◐Partially SupportedLiver ultrasounds can be used to compare liver fat levels in individuals, including those on ketogenic diets.

◐Partially SupportedExcess dietary fructose does not alter gut microbiota or permeability in humans.

◐Partially SupportedExcessive gluconeogenesis, driven by insulin resistance and elevated cortisol, causes hepatic insulin resistance and non-alcoholic fatty liver disease.