How do I lower my risk of non-alcoholic fatty liver disease?

Our read is that managing glucose handling by reducing excess carbohydrates and favoring complex carbohydrates is important for individuals with fatty liver disease, as excessive de novo lipogenesis can lead to fatty liver and elevated triglycerides, according to Peter Attia.

Our read is that choline supplementation has been shown to improve non-alcoholic fatty liver disease, and choline deficiency can cause fatty liver, as noted by Peter Attia and Paul Saladino.

Our read is that reducing intake of certain polyunsaturated fatty acids, especially linoleic acid from seed oils, may be beneficial, as these have been linked to mitochondrial dysfunction and NAFLD development by Paul Saladino.

To lower the risk of NAFLD, our read is that individuals should manage glucose handling by reducing excess carbohydrates and favoring complex carbohydrates, as suggested by Peter Attia. Our read is that choline supplementation may be beneficial, as indicated by Peter Attia and Paul Saladino. Our read is that replacing soybean oil with oils lower in linoleic acid, such as olive pumice oil or canola oil, may decrease fasting insulin levels and improve weight loss, according to Paul Saladino. Our read is that avoiding non-stick cookware may be advisable due to PFOA, a chemical linked to an increased risk of fatty liver disease, as noted by Bryan Johnson. Our read is that limiting red wine to less than one glass per day may prevent excessive calorie intake and fatty liver, as suggested by Andrew Huberman.

• 01Polyunsaturated fatty acids may be disadvantageous long-term for progression from steatosis to NASH (Peter Attia, 1x).
• 02Excessive de novo lipogenesis can lead to fatty liver and elevated triglycerides (Peter Attia, 3x).
• 03Animals depleted of polyunsaturated fatty acids are resilient to various assaults and protected against liver cancer (Paul Saladino, 1x).
• 04Managing glucose handling by reducing excess carbohydrates and favoring complex carbohydrates is important for individuals with fatty liver disease (Peter Attia, 2x).
• 05Fructose may be more injurious than glucose when consumed as a large bolus from liquid sources due to its direct path to the liver (Peter Attia, 1x).
• 06Choline supplementation has been shown to improve non-alcoholic fatty liver disease, and choline deficiency can cause fatty liver (Peter Attia, Paul Saladino, 7x).
• 07High triglycerides that cannot be stored in adipocytes can be deposited as ectopic fat in organs like the liver, pancreas, and heart (Paul Saladino, 1x).
• 08ER-300 improved key liver health biomarkers in an animal model of MASH (David Sinclair, 1x).
• 09Low-dose glyphosate exposure may contribute to non-alcoholic fatty liver disease (Paul Saladino, 4x).
• 10Ethnicity influences the lipidology of fatty liver disease, with African Americans generally having lower VLDL and triglycerides even with type 2 diabetes, while Hispanic patients with diabetes typically have higher triglycerides and VLDL and are more susceptible to NAFLD (Peter Attia, 1x).
• 11Replacing soybean oil with oils lower in linoleic acid, such as olive pumice oil or canola oil, in males with non-alcoholic fatty liver disease, significantly decreased fasting insulin levels and improved weight loss (Paul Saladino, 1x).
• 12Dietary linoleic acid is required for the development of experimentally induced alcoholic liver injury in rats (Paul Saladino, 3x).
• 13Excess linoleic acid from seed oils accumulates in cell and mitochondrial membranes, contributing to mitochondrial dysfunction, increased aldosteronereductase activity, glucose-to-fructose conversion, and potentially NAFLD in insulin-resistant individuals (Paul Saladino, 1x).
• 14Pure fructose is poorly absorbed by humans, leading to malabsorption, bacterial colonization, endotoxin production, and subsequent liver issues (Paul Saladino, 1x).

Our read is that restricting choline and carnitine may negatively impact population health and worsen non-alcoholic fatty liver disease, as noted by Paul Saladino. Our read is that a study on tert-butyl bean for fatty liver disease found no difference in hepatic fat, body weight, inflammatory markers, glycemic markers, or liver function tests between placebo, regular dose, and double dose groups, according to Andrew Huberman. Our read is that elevated ALT levels above 48 U/L are alarming, as stated by Peter Attia. Our read is that for individuals with non-alcoholic fatty liver disease, overconsumption of fat can lead to storage as triglycerides rather than liver processing, as noted by Paul Saladino. Our read is that hemochromatosis can lead to problems with the liver, insulin sensitivity, heart, skin darkening, and increased risk of liver cancer, according to Paul Saladino. Our read is that avoiding non-stick cookware may be advisable due to PFOA, a chemical linked to a 169% increased risk of fatty liver disease in adolescents per doubling of exposure, as suggested by Bryan Johnson. Our read is that previous studies underestimating de novo lipogenesis were flawed due to using healthy, glycogen-depleted individuals who were not habitual fructose consumers, as stated by Peter Attia. Our read is that Intralipid can cause liver failure, leading to liver transplants, and many infants with short gut syndrome die from its use, according to Paul Saladino. Our read is that relying solely on AST, ALT, and NASH scores for liver assessment carries a risk of missing the underlying cause of injury, inflammation, or fibrosis, as noted by Peter Attia. Our read is that consuming large amounts of polyunsaturated fats from marine omega-3 oils can lead to acute liver failure, according to Paul Saladino. Our read is that corn oil is detrimental to rats, causing diabetes, non-alcoholic fatty liver disease, and other problems, as noted by Paul Saladino. Our read is that drinking more than one glass of red wine per day can lead to excessive calorie intake and fatty liver, as stated by Andrew Huberman. Our read is that sorbitol, a sugar alcohol, can produce fructose and may overwhelm the liver's capacity to process it, according to Paul Saladino. Our read is that excessive accumulation of fat in the liver due to impaired fat export is a negative health outcome, as noted by Paul Saladino.

Our read is that new controlled metabolic ward studies isolating specific dietary inputs or outputs for their impact on NAFLD in humans would change the verdict, as noted by Peter Attia. Our read is that further research on the potential relationship between MTHFR gene activity, choline metabolism, and fatty liver disease could also alter the verdict, as suggested by Peter Attia.