Should I take folate?

Our read is that folate, especially in its natural forms like methylfolate, is important for various bodily functions, including DNA methylation, cell division, and fertility.

However, experts strongly advise against consuming folic acid, a synthetic form, due to concerns about poor conversion, potential negative health outcomes, and its association with reduced immune function and certain cancers.

Individuals with MTHFR mutations may particularly benefit from supplemental methylfolate, while those with existing cancer should exercise caution with folate supplementation.

For anxiety, Paul Saladino suggests a trial of methylated B vitamins, including methylfolate (~1mg) and TMG (~600mg). For those trying to conceive, Andrew Huberman recommends prenatal vitamins with folic acid, CoQ10, omega-3 fatty acids, and vitamin D before pregnancy. Paul Saladino also notes that betaine (TMG) or a combination of methylfolate and methyl B12 can ensure adequate methyl group supply.

• 01Paul Saladino suggests a trial of methylated B vitamins, including methylfolate (~1mg) and TMG (~600mg), for individuals experiencing anxiety.
• 02Peter Attia states that folic acid is important for anyone trying to get pregnant.
• 03Paul Saladino notes that methylfolate slows down the activity of the GNMT gene.
• 04Peter Attia claims that folate is utilized in DNA methylation.
• 05Andrew Huberman states that folic acid is important for preventing neural tube defects, cell division, and ovarian follicle and egg growth.
• 06Paul Saladino indicates that individuals with MTHFR mutations may experience severe symptoms if they consume folic acid and processed grains.
• 07Paul Saladino suggests that betaine (TMG) or a combination of methylfolate and methyl B12 can be used to ensure adequate methyl group supply.
• 08Paul Saladino notes that individuals with the MTHFR 677CT polymorphism may require more folate or supplemental methylfolate, and adequate riboflavin and niacin.
• 09Paul Saladino states that methylfolate converts homocysteine into methionine, which can downregulate catacholamines.
• 10Paul Saladino claims that dietary folate, not folic acid, is required for the methionine/folate cycle.
• 11Andrew Huberman recommends that prenatal vitamins with folic acid, CoQ10, omega-3 fatty acids, and vitamin D should be taken before pregnancy to optimize nutrient status and support mitochondrial health for egg quality.

Paul Saladino strongly advises avoiding folic acid in supplements and food due to poor conversion and potential issues with unmetabolized folic acid, which he states can lead to reduced immune function, is associated with some cancers, and may cause neurologic development issues. He also warns that foods containing folic acid are not recommended because excess amounts can block folate receptors. Andrew Huberman and Rhonda Patrick caution that supplementing with folate when cancer cells are present could promote their growth. Paul Saladino also notes that taking excessive methylfolate can lead to over-methylation, requiring caution and monitoring of homocysteine levels. He also suggests giving children a week off from folic acid as a reasonable consideration.

The verdict would change if new evidence emerged demonstrating the safety and efficacy of synthetic folic acid for general supplementation, or if studies showed that natural folate forms consistently promote cancer growth in healthy individuals.