Natural folate precursors and riboflavin, abundant in organ meats like heart and liver, are crucial for supporting MTHFR function.

“there are some B vitamins in meat but there's not a lot of Foley not a lot of biotin not a lot of riboflavin where are those there's some in eggs but they're mostly found in liver livers a fantastic source of riboflavin I had a really interesting discussion with dr. Benton Lynch on my podcast about MTHFR and one of the more compelling things that we know about this MTHFR enzyme which is methylene tetrahydrofolate reductase most of your listeners will probably be familiar it's an enzyme that makes 510 methylene tetrahydrofolate into el methylfolate is that that enzyme can be polymorphic and if we don't give our bodies enough riboflavin specifically then people with polymorphisms in that enzyme can have dysfunction of the enzyme and not make enough al methylfolate which leads to rising almost cysteine”

“you're gonna easily get it eating liver and egg yolks help there's a few other views that are high in riboflavin”

“I think that's a real testament to the fact that perhaps that's actually what's going on that we need to get adequate riboflavin and I love constructing a diet from these first principles and thinking all right if I want to get adequate vitamin A if I want to get adequate riboflavin if I want to get adequate pyridoxamine and b6 what do I have to eat and the simplest thing that falls out of that for me I'm biased but the simplest thing that falls out of that for me time and time again is animal foods nose to tail if you eat muscle meat and organs and fat you'll basically get everything like every single thing and you'll get adequate riboflavin”

“if people do not nose-to-tail they could certainly not get enough riboflavin they may meet the RDA for riboflavin but I think for many of people that I work with who have any polymorphism of MTHFR whether it was 12 98 or 677 unless they are getting significantly more than the RDA to the range of 2 to 3 milligrams of riboflavin per day which as you have pointed out can really only be obtained in organs liver and kidney here are the best sources of that”

“personally i have been able to maintain my homocysteine very low by eating plenty of riboflavin whereas riboflavin it's in oregon meats liver and heart”

“here's methylene tetrahydrofolate reductase it takes this 510 methylene tetrahydrofolate and converts it to 5-methylfolate and then methylfolate 5-methylfolate goes through methionine synthase which is a b12 to fit dependent enzyme to convert homocysteine to methionine b6 is involved in that conversion as well and mthfr has riboflavin as a cofactor so here we are back to riboflavin yet again you need that to be optimal and really the only places i've seen that are from animal foods specifically meat and organs”

“so i don't have to supplement with methylfolate which is another compound that is found in liver that's not found in muscle meat but i don't have to supplement with methylfolate with an mthfr polymorphism because i get enough riboflavin from heart and liver”

“and those i'm thinking whenever i think riboflavin i think about organs because heart and liver such a good source of riboflavin”

“if your homocysteine i believe is over eight i would increase the amount of riboflavin in your diet where do you get riboflavin liver and heart are the best sources of riboflavin”

“you could get folate precursors that naturally occur in nature and rlen which actually is an interesting B vitamin because it's very difficult to get enough riboflavin unless you eat heart and liver it just doesn't occur it's not in muscle meat or supplement or supplement with riboflavin but naturally occurring so you I love what you were saying a lot of these things look complicated and you can biohack your way to pmf and light red light beds all these things but you can also go outside take your sun take your shirt off in the sun go in the o and you can also eat whole foods that mimic what our ancestors would have done and so if you get liver with vitamin A and with folate that's naturally occurring and with um you know enough riboflavin liver and heart give people a lot of riboflavin that's where we get most of it”